Oasis Sample Extraction Products

Oasis Solid-Phase Extraction (SPE) Products

Faster, cleaner, and simpler SPE starts here

Faster, cleaner, and simpler SPE starts here

Analytical chemists worldwide use SPE to remove interfering matrix compounds and enrich the analyte of interest to ensure the generation of high-quality data.

Waters Oasis SPE products come in a broad range of sorbents and an array of formats. With Oasis products, you can meet a wide variety of sample preparation needs, from simple and fast sample matrix clean-up to more complex sample preparation challenges.

Oasis SPE products deliver unmatched purity, consistency, and quality for sample analysis. Along with seven different SPE chemistries, Oasis SPE products use universal to customized protocols to handle your unique sample.

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Oasis PRiME MCX SPE Plates & Cartridges Oasis Sample Extraction Products
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Specifications

Overview

  • Fully water-wettable sorbents increase reproducibility and enable elimination of condition and equilibration steps
  • Co-polymer pH stable from 0–14 with no secondary silanol activity
  • Optimal sensitivity for small molecule and therapeutic peptide analysis
  • Reduced matrix effects for LC-MS/MS analyses
  • Unsurpassed selectivity
  • Consistent retention and capacity, yielding the highest SPE recovery
  • Reduces variability in analytical results and increases robustness of analysis

Recommended Use: For the fastest, cleanest, and simplest approach to SPE-LC-MS/MS method development.

Solid-Phase Extraction Chemistries

Solid-Phase Extraction Chemistries
Oasis PRiME HLB
  • Multi-purpose hydrophilic-lipophilic balanced reversed phase sorbent for acids, bases, and neutrals
  • Cleaner samples in fewer steps with simple three-and two-step protocols, no SPE expertise required
  • Removes 95% of common matrix interferences, such as proteins, salts, phospholipids, and pigments
  • No sorbent conditioning or equilibration steps required
  • Faster, more predictable analysis time

Ideal for reversed-phase SPE clean-up of samples in routine analysis.

Oasis PRiME MCX
  • Mixed-mode Cation eXchange sorbent to selectively retain, concentrate and elute basic compounds
  • Reversed-phase and ion-exchange functionality for orthogonal sample preparation
  • Cleaner samples in fewer steps with simple and fast 3 and 4-step protocols
  • Removes 99% of phospholipids from complex sample matrices
  • No sorbent conditioning or equilibration steps required
  • Faster, more predictable analysis time
  • Highly reproducible target analyte recoveries

Ideal for basic compound specificity while removing matrix interferences in a simple clean-up.

Oasis HLB
  • Multi-purpose hydrophilic-lipophilic balanced reversed phase sorbent
  • Provides high capacity for acids, bases, and neutrals

Ideal for ultra-high capacity of very polar compounds.

Oasis MCX
  • Mixed-mode Cation eXchange sorbent for bases
  • Increased analyte specificity and sensitivity
  • Reversed-phase and ion-exchange functionality for orthogonal sample preparation

Ideal for selective retention of basic analytes.

Oasis MAX
  • Mixed-mode Anion eXchange for acids
  • Increased analyte specificity and sensitivity
  • Reversed-phase and ion-exchange functionality for orthogonal sample preparation

Ideal for selective retention of acidic analytes.

Oasis WAX
  • Weak Anion eXchange mixed-mode sorbent for strong acidic compounds
  • Increased analyte specificity and sensitivity
  • Reversed-phase and ion-exchange functionality for orthogonal sample preparation

Ideal for improved retention of strong acidic compounds.

Oasis WCX
  • Weak Cation eXchange mixed-mode sorbent for strong basic compounds
  • Increased analyte specificity and sensitivity
  • Reversed-phase and ion-exchange functionality for orthogonal sample preparation

Ideal for improved retention of all basic analytes, especially strong bases.

Oasis Format

Oasis Format
Oasis μElution Plate
  • Patented μElution plate design
  • No evaporation and reconstitution necessary due to elution volumes as low as 25 µL
  • Ideal for SPE clean-up and analyte enrichment of small sample volumes
  • Compatible with most liquid-handling robotic systems for automated, reliable high-throughput SPE (HT-SPE)
Oasis 96-Well Sample Extraction Plates
  • Innovative, award-winning two-stage well design
  • High throughput and high recovery
  • Compatible with most liquid-handling robotic systems for automated, reliable high-throughput SPE (HT-SPE)
Oasis Syringe-Barrel Cartridges
  • Ultra-clean syringe barrel and frits
  • Available in cartridges ranging from 1 cc to 60 cc
  • Flangeless syringe-barrel cartridges available in 1 cc, 3 cc, and 6 cc sizes
  • Plus-style cartridges with Luer inlet hub and outlet tip, compatible with hand-held syringes
Oasis Glass Cartridges
  • Ultra-clean glass syringe with Teflon® frit
  • For trace level detection and analysis at part-per-trillion (PPT) levels
  • Available in 5 cc (200 mg) configuration
Oasis On-Line Columns and Cartridges
  • For rugged, reproducible, and ultra-fast on-line analysis
  • Wide choice of configurations, particle sizes, and sorbent chemistries
  • Available with all six patented Oasis sorbents—PRiME HLB, HLB, MCX, MAX, WCX, and WAX
  • High recovery and reproducible results for a wide range of compounds
  • Cartridge format for use with Spark Holland Prospekt-2™/Symbiosis™ systems also available

Sample preparation, improved

Improving various aspects of chromatography and mass spectrometry analyses often starts with sample preparation.  Solid-phase extraction (SPE) or "liquid-solid phase extraction" is a sample preparation technology that uses particles of chromatographic packing material, usually in a cartridge or 96-well plate format, to chemically separate different analytes and aid in removing matrix components in a sample.   

SPE is a proven sample preparation tool for simple sample matrix removal, including common interferences like proteins, salts, fats and phospholipids. This matrix removal provides many benefits, including matrix effect reduction and an increase in sample concentration and analyte specificity. Matrix removal also significantly simplifies chromatographic complexity by reducing the number of interfering peaks in the LC and reducing signal suppression by providing clean samples for the MS.

Get the cleanest extracts with the Oasis 2x4 method

Having a variety of tools for method development allows separation scientists to optimize protocols for maximum sensitivity and selectivity. The Oasis 2x4 method for SPE sorbent and protocol selection for acids, bases, and neutrals produces the cleanest extracts – all by eliminating matrix interferences and sample variability. Get the flexibility to extract acids, bases, and neutrals with high SPE recoveries while removing matrix components that may interfere with analysis with our two protocols and four sorbents. By following the simple steps outlined in the Oasis 2x4 method, you can achieve high recoveries and the cleanest extracts.

Isolate your compounds with the Oasis HLB method

Solid-phase extraction (SPE) method development starts with knowledge of the sample matrix—the nature and relative concentration of the analytes of interest and potentially interfering endogenous compounds. The right sorbent and solvents are selected for load, wash, and elute steps, resulting in the creation of rugged, reliable, and selective protocols. The Oasis HLB method is a generic protocol used to isolate a broad range of acidic, basic, and neutral compounds from a wide spectrum of matrices.

Multiple contaminant analysis with the 2-step pass-through protocol

If you are doing multiple residue screening of veterinary drugs, pesticides and mycotoxins in various food matrices, you may be facing a high concentration of organic solvents. With our simple 2-step protocol (pass-through SPE), you can remove matrix interferences quickly if your samples contain a high concentration of organic solvent(s) and concentration and/or salt removal is not required. It can be used as the clean-up method following QuEChERS extraction, saving you significant time compared to the traditional dispersive SPE method - all while achieving superior clean-up.

To do pass-through SPE, Waters offers 2 convenient and flexible formats:

  • Traditional-style cartridges compatible with vacuum and positive pressure manifolds 
  • "Plus" style cartridges that can be used without manifolds when connected to a displacement syringe

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Offers and Discounts

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Oasis Solid-Phase Extraction (SPE) Products

Oasis Solid-Phase Extraction (SPE) Products from Waters offer unparalleled performance and flexibility in sample preparation, enabling scientists to achieve high levels of precision and reproducibility across various analytical applications. Designed to improve the extraction, concentration, and purification of analytes, Oasis SPE products are an essential tool for any laboratory working with complex biological, pharmaceutical, environmental, or food samples. With a range of chemistries and formats available, these products deliver superior results, ensuring clean, high-quality samples for downstream analysis.

A key feature of Oasis SPE products is their versatility in handling both polar and non-polar compounds, making them suitable for a wide range of analyte extractions. Whether you are working with highly hydrophilic or hydrophobic compounds, Oasis SPE cartridges and plates provide the selective retention and elution needed to isolate your target analytes with high efficiency. The innovative chemistries—such as Oasis HLB, Oasis MCX, Oasis MAX, and Oasis WAX—enable you to optimize your extraction protocol to match the specific characteristics of your samples, ensuring you get the most out of your SPE process.

The Oasis SPE products have a high capacity and retention efficiency, which translate into more consistent and reliable extractions. This high capacity is achieved through the use of advanced, water-wettable sorbents that ensure optimal retention of analytes, even under difficult sample conditions. These water-wettable sorbents allow for improved flow rates and reduced channeling, resulting in more efficient sample processing and enhanced reproducibility across extractions. Whether you are working with plasma, urine, soil, or food matrices, Oasis SPE products provide the reliability needed to meet your analytical demands.

Oasis SPE products are available in a variety of formats, including cartridges, plates, and 96-well plates, to accommodate different sample volumes and throughput requirements. This flexibility allows you to scale your sample preparation workflow according to your lab’s needs, whether you are performing single-sample extractions or processing large sample sets in high-throughput environments. The different formats also provide compatibility with both manual and automated SPE systems, making it easier to integrate Oasis products into your existing laboratory workflow.

Oasis HLB, one of the most widely used Oasis SPE chemistries, is known for its balanced retention of both polar and non-polar compounds, offering excellent flexibility across a wide range of sample types. For more selective extractions, Oasis MCX and MAX provide strong cation-exchange and anion-exchange capabilities, respectively, ensuring optimal retention and elution of charged analytes. Additionally, Oasis WAX combines hydrophilic-lipophilic balance with weak anion-exchange properties, making it ideal for acidic compounds in complex matrices.

These chemistries, combined with Waters' rigorous manufacturing standards, ensure that Oasis SPE products consistently deliver high-quality results across a variety of sample preparation challenges. The superior performance and reproducibility of these products allow scientists to confidently process samples, knowing that they are achieving reliable and repeatable extractions every time.

Oasis Solid-Phase Extraction (SPE) Products from Waters provide the flexibility, efficiency, and reliability needed to streamline your sample preparation workflows. With a wide range of chemistries and formats available, Oasis SPE products are designed to meet the diverse needs of modern analytical laboratories, ensuring consistent performance and high-quality results in every application.

FAQs about Oasis Solid-Phase Extraction (SPE) Products

1. What chemistries are available in the Oasis SPE product line?
Oasis SPE products come in several specialized chemistries to meet a wide range of extraction needs. These include: Oasis HLB, which offers a hydrophilic-lipophilic balance ideal for both polar and non-polar compounds. Oasis MCX, which provides strong cation exchange for basic analytes. Oasis MAX is designed for strong anion exchange, targeting acidic compounds. Oasis WAX combines hydrophilic-lipophilic balance with weak anion exchange, making it perfect for acidic analytes in complex matrices. Each chemistry is tailored to specific extraction challenges, ensuring consistent, high-performance results for a variety of sample types.

2. What formats are available for Oasis SPE products?
Oasis SPE products are available in multiple formats to accommodate different sample volumes and throughput requirements. You can choose from traditional cartridges for manual single-sample extractions or 96-well plates for high-throughput workflows. The various formats are compatible with both manual and automated systems, providing flexibility for labs of all sizes and capacities.