VanGuard Column Protection

VanGuard Column Protection

Protect and prolong analytical column lifetime

Protect and prolong analytical column lifetime

Even under the best conditions, analytical LC columns deteriorate over time from chemical or particulate contamination. With VanGuard Column Protection products, you can now achieve maximum lifetime and performance from your columns.

VanGuard column products are optimized to protect and prolong analytical column lifetimes without compromising chromatographic performance. Available in a wide selection of particle sizes and stationary phases across HPLC, UHPLC, and UPLC, VanGuard Column Protection products are ideally suited for the physical and chemical protection of all Waters analytical columns.

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Specifications

Overview

  • Remove particulates and chemical contamination found in samples and mobile phases
  • Maintain separation resolution and efficiency by minimizing chromatographic peak dispersion and tailing with low dead volume design
  • Eliminate leaks and voids by connecting directly to Waters UPLC, HPLC, and UHPLC columns
  • Compatible with pressures up to 18,000 psi for UPLC and UHPLC columns

Recommended Use: To extend LC column lifetime while maintaining chromatographic performance.

VanGuard Column Protection Characteristics

VanGuard Column Protection Characteristics
VanGuard Cartridge Column (2.1 mm)
  • Use with 2.1 mm or 3.0 mm HPLC/UHPLC Columns
  • Sorbent Particle Size: >2 µm
  • VanGuard Dimension: 2.1 x 5 mm
VanGuard Cartridge Column (3.9 mm)
  • Use with 3.9 mm or 4.6 mm HPLC/UHPLC Columns
  • Sorbent Particle Size: >2 µm
  • VanGuard Dimension: 3.9 x 5 mm
VanGuard Pre-column
  • Use with 2.1 mm or 3.0 mm ACQUITY UPLC Columns
  • Sorbent Particle Size: <2 µm
  • VanGuard Dimension: 2.1 x 5 mm
VanGuard FIT Cartridge Column (3.9 mm)
  • Use with 4.6 mm MaxPeak Premier FIT Columns
  • Sorbent Particle Size: 1.6 µm and up
  • VanGuard Dimension: 3.9 x 5 mm
VanGuard FIT Cartridge Column (2.1 mm)
  • Use with 2.1 mm MaxPeak Premier FIT Columns
  • Sorbent Particle Size: 1.6 µm and up
  • VanGuard Dimension: 2.1 x 5 mm

Remove particulate and chemical contamination

Complex sample matrices encountered in pharmaceutical, natural product, environmental, and industrial chemical analysis prematurely shorten analytical column lifetime and degrade chromatographic performance. VanGuard Column Protection products help improve analytical column performance by removing particulate and chemical contamination that may be present in the mobile-phase stream. The low dead volume design minimizes chromatographic peak dispersion and tailing to maintain separation resolution and efficiency.

Pre-columns maintain UPLC column efficiency

With the low dispersion, one-piece design of the VanGuard Pre-column, you can achieve a holistic approach of higher efficiency, greater resolution, and increased throughput with ACQUITY UPLC separations. The pre-column connects directly to the inlet of the ACQUITY UPLC Column and is available in all ACQUITY UPLC Column stationary phases.

Cost-effective protection for HPLC and UHPLC columns

VanGuard cartridges and pre-columns are a universal solution to extend all HPLC, UHPLC, and UPLC column lifetimes. Simply replace the cartridge instead of your more expensive analytical column to regenerate the original separation performance. The reusable holder is designed with an adjustable ferrule so that it can be attached to any column inlet. The cartridges provide column protection over a wide variety of separation conditions, while the low volume design maintains resolution and separation efficiency during routine use.

A breakthrough in guard column performance

VanGuard FIT (Fully Integrated Technology) represents a more purposeful approach to guard column design and functionality, providing unprecedented ease of use coupled with an ultra-low dispersion format. The innovative all-in-one guard/column design translates to optimal performance for even the most critical separations.

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VanGuard Column Protection
Maximize the performance and lifespan of your analytical columns with VanGuard Column Protection products. Designed to protect against chemical and particulate contamination, these innovative solutions ensure that your columns deliver consistent results over extended use. Whether you"re working with HPLC, UHPLC, or UPLC systems, VanGuard Column Protection products safeguard your investment while maintaining the high-quality chromatographic performance you expect.

Analytical LC columns naturally deteriorate over time, especially when exposed to challenging sample matrices in applications such as pharmaceutical, environmental, or industrial chemical analysis. VanGuard products prevent premature wear by effectively removing particulate and chemical contaminants from samples and mobile-phase streams. This not only extends column life but also preserves separation resolution and efficiency. The low dead volume design of VanGuard products minimizes chromatographic peak dispersion and tailing, ensuring your results remain sharp and accurate.

Available in a wide selection of particle sizes and stationary phases, VanGuard Column Protection products are compatible with all Waters analytical columns and fit seamlessly into your existing workflows. With pressure compatibility up to 18,000 psi, they are especially suited for the demanding requirements of UPLC and UHPLC systems. VanGuard cartridges and pre-columns offer a cost-effective alternative to column replacement, allowing you to regenerate original separation performance by simply replacing the cartridge.

VanGuard Pre-columns, specifically designed for ACQUITY UPLC systems, feature a one-piece, low-dispersion design that connects directly to the inlet of the column. This configuration ensures higher efficiency, greater resolution, and improved throughput without introducing additional chromatographic effects. Available in all ACQUITY UPLC Column stationary phases, VanGuard Pre-columns provide targeted protection while preserving the integrity of your separations.

For even greater convenience and performance, VanGuard FIT (Fully Integrated Technology) offers an all-in-one guard column design. This breakthrough in guard column performance delivers an ultra-low dispersion format, ensuring optimal separation performance equivalent to a column without a guard. The integrated design eliminates additional connections, reducing the potential for leaks or voids while simplifying setup and maintenance.

VanGuard Column Protection products are available in multiple configurations to meet a variety of analytical needs:

By using VanGuard Column Protection products, you can achieve consistent, high-quality separations while protecting your investment in analytical columns. Experience the benefits of reduced maintenance costs, prolonged column life, and preserved chromatographic performance with these versatile and cost-effective solutions.

Trust VanGuard Column Protection to keep your lab running efficiently and effectively, ensuring reliable results with every analysis.

FAQs About Waters VanGuard Column Protection

1. What is Waters VanGuard Column Protection?
Waters VanGuard Column Protection is a pre-column filter that protects your analytical column from contaminants and extends its lifetime.

2. How does Waters VanGuard Column Protection work?
Waters VanGuard Column Protection works by trapping contaminants before they reach the analytical column. It uses a replaceable cartridge that can be easily changed without interrupting your analysis.

3. What types of contaminants can Waters VanGuard Column Protection remove?
Waters VanGuard Column Protection can remove a wide range of contaminants, including particulates, proteins, and phospholipids.

4. Can Waters VanGuard Column Protection be used with any analytical column?
Yes, Waters VanGuard Column Protection can be used with any analytical column, regardless of the manufacturer.

5. How often should I replace the Waters VanGuard Column Protection cartridge?
The frequency of cartridge replacement depends on the sample matrix and the level of contaminants. However, Waters recommends replacing the cartridge every 2-4 weeks or after processing 50-100 samples.