Adding Mass Detection to Routine Peptide-Level Biotherapeutic Analyses with the ACQUITY QDa Detector
In previous work, it was shown that the ACQUITY QDa Detector provides a complementary detection technique to optical detection for monitoring biotherapeutics, and how it can improve the productivity of a single workflow. Cost effective techniques that add value and can be implemented into existing workflows with minimal effort are highly desirable in the pharmaceutical industry. A natural extension of this work was to evaluate the performance of the ACQUITY QDa Detector using a representative biotherapeutic drug.
In this work we demonstrate that the ACQUITY QDa Detector is compatible with conventional LC mobile phases and is able to detect and accurately report mass information for peptides over a wide molecular weight range typical of biotherapeutic peptide maps. These results establish the ACQUITY QDa Detector as an ideal addition for the biopharmaceutical analyst’s lab that will afford increases in productivity and the confidence of data analysis for routine peptide analysis assays.
Related application: Complementing Routine Peptide Monitoring Using the ACQUITY QDa Mass Detector
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