This white paper provides basic understanding and guidance in the configuration of an ACQUITY UPLC System – specifically, an ACQUITY UPLC H-Class Bio – equipped with an FLR detector and an ACQUITY QDa Mass Detector (performance model) for the analysis of RapiFluor-MS-labeled glycans.
The fundamentals of mass detection theory, a detailed system configuration, and method settings are discussed. A best practices section is also provided as a diagnostic tool to qualitatively guage the performance of the system when configured with both an FLR and a mass detector, to offer guidance on improving system performance.
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