Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs! Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs!
Using Mass Detection as an Orthogonal Technology to Improve Routine Analysis of Biotherapeutics
This application note demonstrates how the addition of an ACQUITY QDa Mass Detector to LC-UV based workflows can improve the analysis of biotherapeutics.
Using DFA as mobile phase additive, an LC-UV/MS-based platform method was developed as an identity test for insulin analogues with high chromatographic resolution and MS sensitivity. Purity and stability tests were also performed on intact or digested insulin analogues, showing improved specificity using orthogonal MS data. Together, the data showed how the addition of the ACQUITY QDa can improve the confidence and productivity when carrying out routine analysis of biotherapeutics.
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