A Comparative Study Using Preparative Reverse Phase Liquid Chromatography and Supercritical Fluid Chromatography of Impurities from a Stressed Pharmaceutical Drug Substance

Library Number:
APNT134989403
Part Number:
720006327EN
Author(s):
Janet Hammond, Russell Mortishire-Smith, Jayne Kirk, and Christopher Howson
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
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This application note compares the use of both preparative RPLC and SFC techniques, discussing the scaling process from the analytical to preparative columns while illustrating the efficiency gains when using preparative SFC to isolate the impurities.


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