Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs! Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs!
Development of a Quantitative UPLC/MS/MS Assay for the Simultaneous Quantification of Acetylcholine, Histamine, and their Metabolites in Human CSF using a CORTECS UPLC HILIC Column to Improve Peak Resolution, Sensitivity, and Speed of Analysis
The method described herein demonstrates the simultaneous quantification of ACh, HA, and their metabolites in human CSF. This application uses a single-step sample preparation, dilution of a 20-µL sample, followed by HILIC UPLC/MS/MS analysis. Using a sub-2-µm particle size, the high efficiency CORTECS UPLC HILIC Column provided resolution from endogenous matrices, increased analyte senstivity, and a short analysis time of 2.5 minutes, thereby resulting in a fast, sensitive, selective, and accurate method that meets the demands of high-throughput bioanalytical drug discovery.
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