Advantages of CORTECS C18 2.7 μm and XBridge BEH Phenyl XP 2.5 μm Columns for the Analysis of a Comprehensive Panel of Pain Management Drugs for Forensic Toxicology
This application note highlights the analysis of a comprehensive panel of opiates, benzodiazepines, and other drugs of abuse. Using either Waters’ 2.7 μm CORTECS C18 Column, or a 2.5 μm XBridge BEH Phenyl XP Column, all compounds were analyzed within 4 minutes with excellent peak shape and narrow peak widths. Maximum backpressures were were respectively 2206 and 3274 psi, enabling the use of these columns on traditional HPLC systems. Perhaps most importantly, baseline separation was achieved between isobaric compounds, allowing for their unambiguous identification and quantification. Whether laboratories prefer the performance and efficiency of the solid-core/superficially porous CORTECS C18 Column, or the unique selectivity of the XBridge BEH Phenyl XP Column, each can be used to rapidly analyze this important group of compounds.
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