This technology brief assess the performance of the ACQUITY UPLC I-Class PLUS System coupled with the Xevo™ TQ-S Mass Spectrometer for the analysis of pharmaceutical drugs used in CYP inhibition assays compared with the ACQUITY UPLC I-Class System.
The ACQUITY UPLC I-Class PLUS System produced results comparable with the ACQUITY UPLC I-Class System for the analysis of pharmaceutical drugs. Retention time reproducibility was excellent with RSD below 0.5%. The ACQUITY UPLC I-Class PLUS System gives confident and reliable results to aid investigators in establishing DDI and CYP experiments in the process of evaluating new drugs.
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