Analysis of Pharmaceutical Drugs Using the ACQUITY UPLC I-Class PLUS System and the Xevo TQ-S Mass Spectrometer

Library Number:
APNT134976284
Part Number:
720006252EN
Author(s):
Kerri M. Smith
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
Related Products:
 

This technology brief assess the performance of the ACQUITY UPLC I-Class PLUS System coupled with the Xevo™ TQ-S Mass Spectrometer for the analysis of pharmaceutical drugs used in CYP inhibition assays compared with the ACQUITY UPLC I-Class System.

The ACQUITY UPLC I-Class PLUS System produced results comparable with the ACQUITY UPLC I-Class System for the analysis of pharmaceutical drugs. Retention time reproducibility was excellent with RSD below 0.5%. The ACQUITY UPLC I-Class PLUS System gives confident and reliable results to aid investigators in establishing DDI and CYP experiments in the process of evaluating new drugs.


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