Development and Validation of a Routine Multi-Residue Method for the Quantitative Determination of Pesticide Residues in Fruits, Vegetables, and Rice Using UPLC-MS/MS
This application note describes the development and validation of a robust, quantitative method for the routine determination of a wide range of LC-amenable pesticides following QuEChERS (DisQuE dispersive sample preparation) procedure and LC-MS/MS using a Waters ACQUITY UPLC I-Class PLUS System coupled to the Xevo TQ-S cronos Tandem Quadrupole Mass Spectrometer.
The results of our internal validation indicate that the method performance meets regulatory guidelines for official control and due diligence testing of pesticides. Calibration characteristics, linearity, sensitivity, and within-lab reproducibility were all shown to be suitable for use with CEN QuEChERS for checking compliance with EU MRLs for pesticide residues. Furthermore, the system is shown to be reliable in routine operation with minimal requirements for user intervention during extended periods of analysis.
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