In this white paper we will learn appropriate and effective clean-up step into the sample preparation protocol will reduce the amount of unwanted co-extractives introduced into the UPLC-MS/MS system. This is important because clean-up is one of the options used to mitigate the impact of matrix effects, but also, and most importantly, because it will reduce the rate at which charging effects occur, and reduces the frequency of intervention for maintenance thus enhancing the robustness of the method.
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