Reliable analytical methods are needed for detection, quantification, and identification of hundreds of pesticide residues in many different commodities. This poster describes the development and validation of a comprehensive method based on GC–MS/MS for the determination of 166 pesticides in rice-based baby food. Extracts were prepared using a published version of QuEChERS for cereals followed by determination with GC-MS/MS. The use of GC-MS/MS utilizing atmospheric pressure ionization (APGC) has been shown to offer significant improvements in performance over electron ionization (EI) for pesticide residue analysis in terms of selectivity, specificity, and speed of analysis. The extremely high sensitivity of the APGC Xevo TQ-XS System was demonstrated with reliable detection for almost all analytes at concentrations as low as 0.0003 mg/kg with an injection volume of 1µL. The method was successfully validated in rice-based baby food using the SANTE guidelines document. The results from analysis of the spikes at both concentrations showed that 91 % and 98 % of the analytes were within the required tolerances for recovery and repeatability, respectively. The method is considered sensitive, specific, accurate, and suitable for the determination of residues of a wide range of GC-amenable pesticides for checking compliance with the specific MRLs set for food intended for infants and young children and has the potential for determination at much lower concentrations.