Efficient Method Development for the Analysis of Naphazoline Hydrochloride, Pheniramine Maleate and Associated Related Substances Using a Systematic Screening Protocol

Library Number:
APNT135111352
Part Number:
720007850EN
Author(s):
Margaret Maziarz, Paul D. Rainville
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
 
ACQUITY QDa Detector - Effortless Integration
 

A systematic screening protocol was used to develop an ultra-high performance liquid chromatography (UHPLC) method for the analysis of naphazoline hydrochloride (HCl) and pheniramine maleate active pharmaceutical ingredients (APIs) and their associated related substances. Following a predefined experimental plan, the major selectivity factors were systematically screened during the study, enabling efficient method development. An Arc Premier System integrated with a PDA detector and an ACQUITY QDa Mass Detector was used to develop a method.

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