This technical brief has highlighted the increased response of the Xevo TQ-S micro when using a preconfigured targeted MRM qualitative testing method; when compared to data collected from the same samples on the Xevo TQD an improvement in the number of true positives was observed. The ACQUITY UPLC I-Class/Xevo TQ-S micro is a highly-versatile instrument for use in clinical research, providing the user with both broad qualitative testing capabilities as well as high analytical sensitivity quantitative detection on the same instrument platform.