A Robust and Sensitive Instrument for Quantification of N-Nitroso Argatroban impurity at 0.3 ppm in Argatroban Drug Product

Library Number:
LITR135116693
Author(s):
Waters
Source:
Waters
Content Type:
Literature
Content Subtype:
Brochures

To overcome the analytical challenges of matrix effect and to improve the spiked recovery for N-Nitroso argatroban impurity in drug product needs a suitable sample preparation technique and chromatographic conditions. Waters Xevo TQ S Cronos coupled with ACQUITY UPLC H-Class PLUS and ACQUITY UPLC HSS T3 Column combination produced robust method for quantification.


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