Identifying improvement opportunities in pharmaceutical product lifecycle management is recommended as a means to improve drug safety and continually expand the body of knowledge in the manufacturing of drug products. The ACQUITY Premier System featuring MaxPeak HPS represents an innovative leap forward in separation science with its ability to reduce analyte/surface interactions and improve chromatographic performance. With the introduction of the fixed-loop design into the ACQUITY Premier System portfolio, scientists can now take full advantage of this novel surface technology to modernize legacy methods and develop assays that are faster, more robust, and more sensitive for better consumer safety in drug products.