N-acetyl Cysteine: A Tool to Perturb SARS-CoV-2 Spike Protein
Library Number:
SCTF135079032
Author(s):
Utsab Debnath, Amrita Mitra, Varun Dewaker, Yenamandra S. Prabhakar, Raghu Tadala, Kiran Krishnan, Padmakar Wagh, Umashankar Velusamy, Chandru Subramani, Shubhra Agarwal, Sudhanshu Vrati, Aastha Baliyan, Anura V Kurpad, Parthasarathi Bhattacharyya, Amit Kumar Mandal
Source:
ChemRxiv
Content Type:
Scientific Publications
Content Subtype:
Article Reprints
Related Products:
SYNAPT G2-Si High Definition Mass Spectrometry
In this study, we have successfully reduced the most accessible disulfide bond (cys391-cys525) at the NTD of purified S1 subunit of SARS-CoV-2 spike protein through thiol/disulfide exchange mechanism, executed by N-acetyl cysteine (NAC), which is a commonly prescribed antioxidant and a mucolytic agent.