Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs! Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs!
Representing a novel and purposeful approach to guard column design and functionality, VanGuard Cartridges and Pre-Columns provide an unprecedented ease of use along with an ultra-low dispersion format. VanGuard Fully Integrated Technology (FIT) is designed to address the restrictions of traditional column design, allowing for sound connections to be made in a simple and reproducible manner while reducing extra-column volume. With these innovations, lab equipment using VanGuard FIT Technology, including the VanGuard Cartridge Holder, allows for optimal performance in even the most critical of separations.
Across pharmaceutical, natural product, environmental, and industrial chemical analysis, the complex sample matrices can often prematurely shorten column lifetime and degrade chromatographic performance. VanGuard Column Protection products improve the performance by removing particulate and chemical contamination that is present in the mobile-phase stream, extending the lifetime of columns and avoiding leaks and connection voids.
VanGuard columns are available in multiple particle sizes and stationary phases, like the XBridge BEH C18 VanGuard Cartridge, 130Å, 3.5 µm, 3.9 mm X 5 mm, 3/pk, making them perfectly suited to the physical and chemical protection of all analytical columns. VanGuard Cartridge Columns consist of two pieces, a holder and a cartridge, but they can be purchased separately. The VanGuard Cartridge Holder allows for the cartridge to be directly attached to the inlet side of an analytical LC column.
As part of the VanGuard system, the VanGuard Cartridge Holder offers minimal chromatographic effects while still optimizing performance in compatible operating pressures up to 18,000 psi (1240 bar). This allows the cartridge holder to offer superior protection across UPLC, UHPLC, and HPLC columns with particle sizes ranging from 5 to 16 µm. This is because the packing materials used in Waters VanGuard products are identical to the packaging materials used in Waters HPLC and UPLC Columns.
How Do I Replace the VanGuard Cartridge?
VanGuard Cartridge Columns are a two-piece design, with a reusable holder and replaceable cartridge. The following steps should be followed for replacement:
First, remove the LC inlet tubing from the column assembly. A 7/16 wrench and 3/8 inch wrench will help detach the cartridge from the holder. The holder does not need to be removed from the analytical column. Discard the old guard column and install the new one.
Then tighten the cartridge using the same wrenches, applying them to the flats on the cartridge holder. Then reattach the LC inlet tubing and apply mobile phase flow to ensure a leak-free collection.
