Adding MS Detection to the Analysis of Small Biotherapeutics Using Waters ACQUITY QDa Detector

资料库号码:
APNT134932751
部件代码:
720005977EN
作者:
Ximo Zhang, Robert Birdsall, and Ying Qing Yu
消息来源:
Waters
内容类型:
应用文章
内容子类型:
应用纪要
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We demonstrate how new technologies, such as the ACQUITY QDa Detector, can be incorporated into existing biopharmaceutical workflows for improved product knowledge that is in accordance with ICH Q10, such as for multiple attribute monitoring (MAM). As an orthogonal detection technique to typical LC-UV assays, the ACQUITY QDa Detector improves assay sensitivity and specificity of small biotherapeutics that range in molecular weight from 5 kDa to 22 kDa. The ACQUITY QDa Detector as an in-line detector enables the simultaneous acquisition of MS information with optical data in LC-UV based workflows for deeper product understanding without compromising productivity.


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