Adding MS Detection to the Analysis of Small Biotherapeutics Using Waters ACQUITY QDa Detector

Library Number:
APNT134932751
Part Number:
720005977EN
Author(s):
Ximo Zhang, Robert Birdsall, and Ying Qing Yu
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
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We demonstrate how new technologies, such as the ACQUITY QDa Detector, can be incorporated into existing biopharmaceutical workflows for improved product knowledge that is in accordance with ICH Q10, such as for multiple attribute monitoring (MAM). As an orthogonal detection technique to typical LC-UV assays, the ACQUITY QDa Detector improves assay sensitivity and specificity of small biotherapeutics that range in molecular weight from 5 kDa to 22 kDa. The ACQUITY QDa Detector as an in-line detector enables the simultaneous acquisition of MS information with optical data in LC-UV based workflows for deeper product understanding without compromising productivity.


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