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Select the ideal Waters HPLC, UPLC, UHPLC, GPC, SFC, or SEC column for your application to simplify methods development, validation, and transfer across your organization.
Select the ideal Waters HPLC, UPLC, UHPLC, GPC, SFC, or SEC column for your application to simplify methods development, validation, and transfer across your organization.


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Waters offers a wide array of column choices and formats, including HPLC, UPLC, UHPLC, GPC, SFC, and SEC, all built on reliable quality manufacturing that ensures that methods developed today will have the same repeatable results tomorrow.
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- Atlantis Premier ColumnsDiscover Atlantis Premier Columns for high-performance liquid chromatography, designed to improve peak shape while mitigating unwanted interactions.
- CORTECS Premier ColumnsEliminate doubt in UPLC, UHPLC, and HPLC analysis applications with CORTECS Premier Columns, designed to increase sample throughput while providing reproducible data for all analytes.
- XSelect Premier ColumnsDiscover XSelect Premier UHPLC Columns designed to improve peak shape and maximize selectivity while mitigating unwanted analyte/surface interactions.
- Gene-Based Therapeutics (GTx) ColumnsAnalyze gene therapeutics to learn about the potency and safety of your sample with Waters Gene Therapeutics (GTx) Size-Exclusion Chromatography (SEC) Columns, designed to provide accurate, high-throughput data.
- SEC ColumnsAnalytical size-exclusion chromatography columns are ideal for aggregate, monomer, and fragment analysis. Separate biomolecules by size in solution with Waters SEC Columns.
- ACQUITY UPLC ColumnsDiscover how to achieve increases in LC efficiency, resolution, sensitivity, accuracy, speed, and reliability with ACQUITY sub-2-μm UPLC particle columns.
- CORTECS ColumnsMaximize resolution and peak capacity for LC separations with CORTECS solid-core columns in 1.6 and 2.7 µm across 7 column chemistries.
- XBridge ColumnsExperience XBridge HPLC and UHPLC Columns, ideal for methods development at extreme temperatures and mobile-phase pH. Explore XBridge BEH Column chemistries today.
- Atlantis ColumnsImprove chromatographic performance, retention, and stability for polar compounds with Atlantis HPLC Columns. Discover Atlantis C18 and HILIC column chemistries now.
- XSelect ColumnsGet superior selectivity and peak shape for basic compounds with XSelect HPLC and UHPLC Columns. Discover our CSH and high-strength silica columns. Visit today.
- ACQUITY APC ColumnsSeparate complex synthetic polymers & macromolecules with ACQUITY Advanced Polymer Chromatography (APC) Columns for superior performance and reliability.
- ACQUITY Premier ColumnsAchieve increases in sensitivity and analyte recovery while reducing column passivation time and mitigating unwanted analyte/surface interactions with ACQUITY Premier Columns.
- AccQ•Tag Columns for Amino Acid AnalysisExperience accurate and reproducible UPLC, UHPLC, and HPLC amino acid analysis with Pico•Tag, AccQ•Tag, and AccQ•Tag Ultra C18 Columns and Derivatization Kits.
- Advanced Purification Glass ColumnsMeet protein purification needs with Advanced Purification glass columns with silica, polymer or soft gel packings, designed for analytical & preparative LC instruments.
- BioResolve ColumnsStreamline analytical challenges associated with mAb characterizations and associated biotherapeutic drug separations with BioResolve Columns.
- BioResolve Premier ColumnsIncrease bioanalysis recovery, reproducibility, and enhance LC and LC-MS sensitivity with Waters BioResolve Premier Columns, reversed-phase ion exchange columns designed for bioanalysis applications
- BioSuite ColumnsIdeal for the isolation, analysis, and characterization of proteins and peptides, BioSuite Columns offer multiple chemistries: C18, cation and anion-exchange, SEC, & Phenyl.
- Delta-Pak ColumnsSeparate and isolate peptides, proteins, and natural products with Delta-Pak HPLC Columns for large molecule separations.
- Enzymate Pepsin ColumnAchieve fast, efficient, and reproducible online protein digestion with shorter sample preparation time with the Enzymate BEH Pepsin Column. Explore now.
- GPC ColumnsSeparate small and large molecules from interfering matrices in foods, pharmaceutical preparations, and natural products with Waters GPC Columns for organic and aqueous separations.
- GTxResolve Premier BEH Amide ColumnsDevelop high resolution, ion-pairing free analysis methods for synthetic oligonucleotides, digested nucleic acids, and capsid proteins with GTxResolve Premier BEH Amide Columns.
- GTxResolve SEC ColumnsReliable and robust critical quality attribute analysis of aggregates for Lipids nanoparticles (LNPs), nucleic acids, and viral vectors using GTxResolve columns.
- Gen-Pak FAX ColumnsPerform complicated synthesis, analysis and other HPLC assays with Gen-Pak FAX Anion-Exchange Columns. Explore our Gen-Pak oligonucleotide synthesis columns now.
- MassPREP On-Line Desalting CartridgesFor a quick, easy and reproducible protocol for desalting acidic, basic and large globular proteins, choose MassPREP On-line Desalting Cartridges.
- MaxPeak Premier OBD Preparative ColumnsMinimize non-specific adsorption (NSA) inherent to preparative chromatography while yielding high-purity results with MaxPeak Premier OBD Preparative Columns.
- MaxPeak Premier Protein SEC ColumnsEnhance your workflow with MaxPeak Premier Protein SEC Columns, size-exclusion chromatography columns for the characterization of proteins and peptides.
- Nano and MicroFlow LC-MS ColumnsMeet high efficiency and selectivity requirements for complex peptide and protein separations with Waters nano and microflow LC-MS Columns.
- Nova-Pak ColumnsGet higher resolution and efficiency for HPLC with Nova-Pak analytical and semi-preparative columns. Discover Nova-Pak C18, C8, Cyano & Phenyl column chemistries.
- Preparative HPLC ColumnsAchieve fast, efficient, lab-scale separations and greater throughput with Waters Preparative HPLC Columns, which provide predictable performance and easily scale from analytical to prep.
- Protein-Pak ColumnsAchieve high-quality LC-based analyses & lab scale purifications of peptides and proteins with Protein-Pak IEX & HIC Columns, designed for use on HPLC and UPLC systems.
- Resolve ColumnsAchieve high retention and high resolution of polar compounds with non-endcapped Resolve Columns available in C18, C8 and Cyano column chemistries.
- SFC ColumnsGet the alternative selectivity of normal-phase with the ease & reliability of reversed-phase chromatography with Waters analytical and prep SFC Columns for chiral and achiral separations.
- Shodex RSpak ColumnsPolymeric reversed-phase columns for basic compounds and applications requiring a broad pH range (2–12). Shodex RSpak Columns chemistries include DE-613 and DS-613.
- SunFire ColumnsGet exceptionally high mass loading for both analytical and preparative columns with SunFire HPLC Columns. Discover SunFire Silica, C8, and C18 columns.
- Symmetry HPLC ColumnsGet predictable analytical performance and ensure batch-to-batch reproducibility with high purity silica-based Symmetry HPLC Columns.
- VanGuard Column ProtectionSafeguard analytical HPLC, UHPLC, and UPLC columns from the effects of damaging particulates and chemical contaminates with VanGuard Cartridges and Pre-columns.
- Waters Insulin HMWP ColumnAnalyze insulin products for impurities with Waters Insulin HMWP Gel Filtration HPLC Columns. Learn about insulin gel filtration column packing now.
- Waters PAH ColumnsGet superior peak identification and quantitation for Polyaromatic Hydrocarbons (PAHs) compounds with Waters PAH C18 HPLC Columns.
- Waters Spherisorb HPLC ColumnsDiscover unique separation selectivities with Waters Spherisorb Columns, the most widely referenced products for analytical and preparative column chromatography.
- XBridge Premier ColumnsExperience XBridge Premier UHPLC Columns, designed to operate under extreme temperatures and mobile-phase pH while mitigating unwanted analyte/surface interactions.
- XTerra ColumnsPerform low and high pH drug discovery, method development and purification separations with XTerra hybrid particle technology HPLC columns. Learn more.
- µBondapak and Bondapak ColumnsSeparate acidic, basic, and neutral compounds with µBondaPak and BondaPak Columns. These HPLC columns are available in phenyl, C18, cyano and NH2 column chemistries.
- µPorasil/Porasil ColumnsGet reliable normal-phase chromatography separations with non-bonded, silica-based μPorasil and Porasil Columns. Research µPorasil/Porasil HPLC Column options.