PFAS Analysis Solutions

PFAS Analysis Solutions

Get ready to conquer your toughest analytical challenges with the ultimate workflow solution in the market, designed to help you tackle the most stringent PFAS limits. From sample preparation to proficiency testing, Waters is dedicated to revolutionizing your PFAS analysis. Team up with Waters today and power towards absolute performance.

Get ready to conquer your toughest analytical challenges with the ultimate workflow solution in the market, designed to help you tackle the most stringent PFAS limits. From sample preparation to proficiency testing, Waters is dedicated to revolutionizing your PFAS analysis. Team up with Waters today and power towards absolute performance.
Contact Sales
Two scientists in protective suits taking water samples from river
Two scientists in protective suits taking water samples from river

Overview

Absolute Power: Conquer your analytical PFAS challenges

Absolute Power: Conquer your analytical PFAS challenges

No matter your PFAS challenge, Waters will strengthen your analytical game plan to achieve performance requirements, including the most stringent levels of single ppq or expanding the analytical scope of EPA draft method 1633 with the Xevo TQ Absolute. Safeguard yourself against contamination and control interference with our PFAS LC Kits and Oasis WAX SPE.

Browse Waters PFAS solutions for comprehensive workflows for sample extraction, screening, quantification, and reporting of PFAS in various water sources, soil, biosolids, biota, food, or other complex matrices with developed methods to help you stay ahead of challenging PFAS performance requirements.

Download PFAS Solutions Infographic

Introducing LC-MS/MS Solution for PFAS Analysis

Applications

PFAS compounds are extremely persistent in the environment. Waters has deep expertise in developing methods for environmental PFAS compounds, including the application notes below.

PFAS compounds are extremely persistent in the environment. Waters has deep expertise in developing methods for environmental PFAS compounds, including the application notes below.

Application Notes

Monitoring levels of PFAS in human biofluids can help us understand exposure levels and pathways.

Testing the presence of PFAS compounds in cosmetics provides critical understanding to avoid adverse health effects from skin exposure.

Monitoring levels of PFAS in human biofluids can help us understand exposure levels and pathways.

Testing the presence of PFAS compounds in cosmetics provides critical understanding to avoid adverse health effects from skin exposure.

Application Notes

Many labs are progressing towards high-resolution mass spectrometry (HRMS) techniques to help them screen for an unlimited number of PFAS targets while providing information on unknown compounds or metabolites of interest. Learn more about HRMS in PFAS analysis with these application notes.

Many labs are progressing towards high-resolution mass spectrometry (HRMS) techniques to help them screen for an unlimited number of PFAS targets while providing information on unknown compounds or metabolites of interest. Learn more about HRMS in PFAS analysis with these application notes.

Application Notes

eBook: Addressing the Global Challenge of PFAS Contamination

In this eBook, we delve into how advanced LC-MS/MS and HRMS technologies are helping scientists and regulators worldwide to tackle PFAS challenges head-on. From sample preparation to data analysis, Waters Corporation stands ready to advance public health and environmental safety by providing the tools needed to measure, manage, and mitigate the impact of PFAS.

In this eBook, we delve into how advanced LC-MS/MS and HRMS technologies are helping scientists and regulators worldwide to tackle PFAS challenges head-on. From sample preparation to data analysis, Waters Corporation stands ready to advance public health and environmental safety by providing the tools needed to measure, manage, and mitigate the impact of PFAS.
Download eBook
Child drinking water from glass

Solutions

Routine or Regulated PFAS Quantitation​

Routine or Regulated PFAS Quantitation​

Achieve Absolute performance and reach lowering regulatory limits

Achieve Absolute performance and reach lowering regulatory limits
Xevo TQ Absolute

Achieve and maintain high performance and productivity with significantly increased sensitivity for negative ionizing compounds with our compact, sustainable tandem quadrupole mass spectrometer.

  • Environmental
  • Drinking Water
  • Food
  • Serum
  • Cosmetics and Personal Care Products

Revolutionize your separations and level up your lab efficiency

Revolutionize your separations and level up your lab efficiency
ACQUITY Premier System

Separate your analytes of interest from system contamination while repeatably achieving reliable retention and chromatographic separation. Reduce the risk of false detections from background contamination with a PFAS-specific LC kit.

  • Environmental
  • Drinking Water
  • Food
  • Serum
  • Cosmetics and Personal Care Products

Research, Non-targeted Screening, and Unknown Identification​

Research, Non-targeted Screening, and Unknown Identification​

Improve your qualitative and quantitative capabilities with its outstanding sensitivity​

Improve your qualitative and quantitative capabilities with its outstanding sensitivity​
Xevo G3 QTof ​​

The unrivalled sensitivity of the Xevo G3 QTof makes it an ideal system for the analysis of challenging per- or poly- fluoroalkyl substances (PFAS). The enhanced TofMRM functionality offers analysts the flexibility to quantify known PFAS, in addition to the screening and investigative capabilities of the QTof for unknown PFAS. ​​
​​
Get to the right answers faster with the powerful screening workflows within the waters_connect software platform. All the tools needed for confident identification and quantification of known or unknown per- or poly- fluoroalkyl substances (PFAS) are conveniently found in a single solution.​

  • Environmental
  • Drinking Water
  • Food
  • Serum
  • Cosmetics and Personal Care Products

Unlock the potential in scientific discovery and advance structural characterization studies in your lab​

Unlock the potential in scientific discovery and advance structural characterization studies in your lab​
SELECT SERIES Cyclic IMS​​

The SELECT SERIES Cyclic IMS facilitates the challenge of finding new and emerging pollutants. Combining Cyclic Ion Mobility with high resolution mass spectrometry adds an extra dimension of separation, that easily distinguishes PFAS class of compounds from matrix or contaminants, and importantly can resolve isomers such as linear and branched PFAS.  In addition, Ion mobility provides confidence in identification through the use of Collisional Cross Section (CCS).

  • Environmental
  • Drinking Water
  • Food
  • Serum
  • Cosmetics and Personal Care Products

Explore the full line of Waters tandem quadrupole mass spectrometers.

Dominate your data review

Dominate your data review
waters_connect for Quantitation

Data review can create bottlenecks in routine laboratory environments. waters_connect for Quantitation is designed to enable ease of use, reduce training burden, and streamline data review, improving your productivity and confidence in PFAS analysis. 

  • Environmental
  • Drinking Water
  • Food
  • Serum
  • Cosmetics and Personal Care Products

Maximize method performance and achieve reliable PFAS quantitation and identification with Waters portfolio of columns and consumables.

Maximize method performance and achieve reliable PFAS quantitation and identification with Waters portfolio of columns and consumables.
ACQUITY Premier Columns

ACQUITY Premier Columns are built on sub-2 µm particle technologies for uncompromised reproducibility. ACQUITY Premier BEH C18 Columns are well-suited for robust and reproducible separation of PFAS analytes, and ACQUITY Premier C18 AX Columns are ideal for emerging short-chain (e.g., GenX) and legacy PFAS.  

  • Environmental
  • Drinking Water
  • Food
  • Serum
  • Cosmetics and Personal Care Products

Extract and concentrate with confidence

Extract and concentrate with confidence
Oasis WAX for PFAS Analysis

Reduce the risk of sample contamination during sample collection, preparation, and analysis with Oasis WAX for PFAS Analysis. The mixed-mode, Weak Anion-eXchange, reverse-phase, water-wettable polymer is quality control tested for 32 PFAS to provide confidence in your results through application-specific, quality control testing. 

  • Environmental
  • Drinking Water
  • Food
  • Serum
  • Cosmetics and Personal Care Products

Streamline your sample preparation process, ensuring efficiency and accuracy

Streamline your sample preparation process, ensuring efficiency and accuracy
Oasis WAX/GCB and GCB/WAX for PFAS Analysis SPE Cartridges

Oasis WAX/GCB and GCB/WAX for PFAS Analysis cartridges undergo a QC lot release test from an accredited PFAS laboratory to ensure low levels of residual PFAS. Designed for use with complex matrices and reproducible and provide recoveries for PFAS that meet the acceptance criteria of EPA method 1633. Compared to loose GCB, extractions are faster by up to 20% (approx. 30 minutes) per sample batch and eliminate four manual steps in the 1633 sample preparation workflow. 

  • Environmental
  • Drinking Water
  • Food

Sample preparation and filtration with confidence

Sample preparation and filtration with confidence
GCB for Use in EPA Draft Method 1633

This graphitized carbon black 25 g bottle is ideal for the adsorption of interferent organics.

  • Environmental
  • Drinking Water
  • Food

Get your analytical system PFAS-ready

Get your analytical system PFAS-ready
PFAS Solution Installation Kits

PFAS Solution Installation Kits provide everything you need to get your Waters analytical system PFAS-ready. The kit includes necessary items to help minimize PFAS-containing components within your system.

  • Environmental
  • Drinking Water
  • Food
  • Serum
  • Cosmetics and Personal Care Products

Rapidly screen food and agricultural samples

Rapidly screen food and agricultural samples
DisQuE, QuEChERS Sample Preparation Products

Waters QuEChERS kits for dispersive solid-phase extraction (d-SPE) analysis make sample prep quick and easy for your multi-residue food and agricultural analysis.

  • Food

Keep pace with evolving analytical methods

Keep pace with evolving analytical methods
Environmental PFAS Proficiency Testing and Reference Materials

Ensuring quality at every turn in your workflow, Waters ERA deliver reference materials you need to be confident about your data and keep pace with evolving analytical methods.

  • Environmental
  • Drinking Water

Accelerate your success with industry-leading support

Accelerate your success with industry-leading support
Waters Services

Explore what’s possible in the reliable determination of PFAS compounds by optimizing your analytical workflow from sample preparation to results reporting. Accelerate your time to results and capabilities in your analysis with our on-site application consultation and industry-leading support.

An experienced team with deep industry expertise

An experienced team with deep industry expertise
Environmental PFAS Proficiency Testing

Waters ERA is here to help laboratories achieve and manage accreditation and advance their quality management programs.

The data speaks for itself

The data speaks for itself
Overlaid chromatograms of PFOA (0.004 ng/L), PFOS (0.02 ng/L), PFBS (0.02 ng/L), and GenX (0.02 ng/L) demonstrating spiked sample extracts (blue) to extraction blanks (orange) and solvent blanks (green).
PFAS recovery in drinking water following sample extraction using Oasis WAX Cartridges and EPA 533 method. All compounds are well within the method recovery guidelines of 70–130%.
With Waters application-specific LC kits, you can reduce the risk of false detections from background contamination (e.g., mobile phase, additives, and tubing).
Comparison of experimental PFAS concentrations with the min/max certified values in an ERA Wastewater Certified Reference Material using the EPA Draft 1633 methodology.

Webinars and Resources

  • Blog

How Waters is Helping to Solve the Global PFAS Problem

How Waters is Helping to Solve the Global PFAS Problem
Read
  • Infographic

Analytical Workflow Solutions for PFAS Analysis Infographic 

Analytical Workflow Solutions for PFAS Analysis Infographic 
Download
  • Infographic

Understanding the USEPA 1633 Draft Method

Understanding the USEPA 1633 Draft Method
Download
  • White Paper

Monitoring PFAS Contamination in a Shared- Space Commercial Lab White Paper

Monitoring PFAS Contamination in a Shared- Space Commercial Lab White Paper
Download
  • White Paper

Enhancing Environmental Testing: Comprehensive Guide to PFAS Analysis Using EPA Method 1633 and LC-MS/MS

Enhancing Environmental Testing: Comprehensive Guide to PFAS Analysis Using EPA Method 1633 and LC-MS/MS
Download
  • Case Study

Adapting to Challenging PFAS Analysis Case Study

Adapting to Challenging PFAS Analysis Case Study
Download
  • Case Study

How the City of Phoenix Built Comprehensive In-House PFAS Testing Capabilities

How the City of Phoenix Built Comprehensive In-House PFAS Testing Capabilities
Download
  • Application Notebook

PFAS Testing

PFAS Testing
Download

Learn more about Waters PFAS Solutions.

Learn more about Waters PFAS Solutions.
Contact Sales
Two scientists in protective suits taking water samples from river
Back To Top Back To Top

PFAS analysis solutions are systems designed to detect and measure per- and polyfluoroalkyl substances (PFAS), commonly known as "forever chemicals" because of their persistence in the environment and human body. PFAS are found in a variety of products. Testing for PFAS is crucial for industries focused on environmental monitoring, food safety, and public health.

These solutions rely on advanced instruments such as liquid chromatography (LC) coupled with mass spectrometry (MS), which are highly sensitive and can detect trace levels of PFAS. Techniques like solid phase extraction (SPE) and QuEChERS are often used to prepare samples, ensuring that PFAS can be isolated from complex materials without interference from other substances.

PFAS testing is usually guided by standardized methods set by regulatory bodies like the EPA and ISO, which ensure consistent and accurate results. Many analysis solutions come with pre-validated workflows, making it easier for laboratories to start testing quickly and reliably. Specialized software is also used to process the data, track results, and maintain quality control, especially in labs that handle large volumes of samples.

Despite their effectiveness, PFAS testing presents challenges, such as detecting very low levels of contamination and preventing cross-contamination in the lab, as PFAS can be found in common laboratory supplies. Labs need to follow strict protocols to avoid these issues during testing.

Turnkey PFAS analysis solutions provide a comprehensive, ready-to-use package that includes the necessary instruments, methods, and support. This makes it easier for laboratories to implement PFAS testing while ensuring regulatory compliance.

To conclude, PFAS analysis solutions are critical for accurately detecting and measuring PFAS in various samples, supporting environmental safety, food security, and public health initiatives as the concern over PFAS contamination continues to grow.