ACQUITY UPLC ELS Detector

ACQUITY UPLC ELS Detector

See more of what you need and see it faster

See more of what you need and see it faster

Increase peak confidence across a wide application range with optimal UPLC/ELS (ELSD) performance in a small footprint. The ACQUITY UPLC Evaporative Light Scattering (ELS) Detector from Waters offers unparalleled performance when monitoring compounds with poor to no ultraviolet/visible response and analytes that do not ionize well in mass spectrometry.

This detector has been designed specifically for ACQUITY UPLC PLUS series systems and engineered for a variety of sample sizes—particularly for high volume or open access environments and anywhere large numbers of compounds are screened rapidly. The ACQUITY UPLC ELS Detector offers a convenient stackable design, easy maintenance, and long lamp lifetimes.

Waters ACQUITY UPLC Evaporative Light Scattering (ELS) Detector. ACQUITY UPLC ELS Detector

Specifications

Nebulizer

Front mounted, snap-in design

Temperature control nebulizer chamber

Heater 0 to 100%, thermally controlled, cooler on/off

Gas

Nitrogen, to be supplied, at least 65 psi

Temperature range drift tube

0.1 °C increments, feedback accuracy to 0.1 °C

Eluent flow rate maximum

100% water at 2 mL/min

Filter setting

Hamming, 0 to 5.0 seconds in 0.1 second increments

Optics

Heated optics bench (constant 50 °C)

Light source

Tungsten halogen polychromatic, front mounted, pre-aligned, user installable

Detector

Photomultiplier tube

Voltage range

0 to 1250 VDC

Range

0.1 to 2000 light scattering units full scale

Physical specifications

Width: 34.3 cm (13.5 inches)

Height: 21.6 cm (8.5 inches)

Depth: 51.8 cm (20.4 inches)

Overview

  • Achieve enhanced compatibility with a variety of detection techniques, providing a more comprehensive UPLC-MS analysis, and ensuring confidence that all components in the sample have been detected
  • Attain precise control over nebulization and desolvation processes for reproducible and reliable measurement of temperature-sensitive samples
  • Achieve simplified set-up and maximized performance over the entire flow rate ranges of ACQUITY UPLC PLUS series systems with the single nebulizer
  • Attain easy maintenance and maximum up-time with the pre-aligned snap-in lamp
  • Improve peak definition and confidence in quantitative results with data rates up to 80 Hz
  • Send a "Stop Flow" signal to LC pump when low gas pressure is detected

Recommended Use: Add a new dimension of performance and system versatility to analyses where compounds have poor to no UV/Vis response.

Features Header

Features Header

See more information per run

The ACQUITY UPLC ELS Detector enables users to see more information per chromatographic run. Evaporative light scattering technology allows the monitoring of compounds that do not have a UV/Vis response and do not ionize well in mass spectrometry. This innovative detector can, therefore, efficiently supplement other detectors.

Achieve ultimate flexibility with multiple detector options

A suite of detectors for samples where some of the components lack chromophores or do not ionize well by mass spectrometry is key to the success of your laboratory.

The ACQUITY UPLC ELS Detector has precise temperature control for the nebulization and desolvation process to cover the entire ACQUITY UPLC PLUS series flow rate range, conveniently allowing you to run samples under different conditions. The detector also provides a snap-in self-aligning lamp and nebulizer for easy serviceability. 

Resolution, sensitivity, and speed designed to suit your needs

Monitoring product batches and carrying quality control of finished goods is intrinsic in pharmaceutical and chemical analysis laboratories. The ACQUITY UPLC PLUS series line of products is critical for the resolution, sensitivity, and speed required in such environments.

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The ACQUITY UPLC ELSD (Evaporative Light Scattering) Detector, is an advanced tool used in chromatography. It boosts sensitivity and selectivity in spotting and measuring compounds, especially those that don't absorb UV light.

Here's what it offers:

How it Works: This detector uses evaporative light scattering to spot analytes. It measures scattered light intensity from particles coming out of the chromatographic column. Unlike UV detectors, it's great for compounds that don't absorb UV light.

Better Sensitivity: It's excellent at spotting compounds at low concentrations, crucial for analyzing complex samples with tiny amounts of target compounds.

Great Selectivity: Besides sensitivity, it's also very good at distinguishing and measuring analytes even when there are other interfering compounds around.

Versatility: It works across different fields like pharmaceuticals, environmental analysis, and food and beverage. It's especially useful for compounds without UV-absorbing properties or those sensitive to heat.

Works with UPLC Systems: It's compatible with Waters' Ultra-Performance Liquid Chromatography (UPLC) systems, ensuring smooth operation and efficient chromatographic separations.

Reliable and Consistent: Known for its reliability and reproducibility, it gives consistent results across multiple tests, ensuring accuracy and data integrity.

Easy to Use: Designed with user-friendliness in mind, it comes with simple software interfaces and easy maintenance, streamlining workflows and reducing downtime.

In essence, the ACQUITY UPLC ELSD Detector is a powerful tool for analyzing compounds in chromatography. It's sensitive, selective, and adaptable for various applications in research, development, and quality control in different industries.

FAQ: ACQUITY UPLC ELS Detector

1.What are the detection limits for the ACQUITY UPLC ELS Detector?
The detection limits of the ACQUITY UPLC ELS Detector vary depending on the nature of the analyte and the operating conditions. Generally, the ELS Detector can detect analytes in the nanogram range, making it highly sensitive to non-volatile and semi-volatile compounds.

2. How does the ACQUITY UPLC ELS Detector compare to traditional detection methods?
The ACQUITY UPLC ELS Detector offers several advantages over traditional UV and fluorescence detectors, especially for compounds that do not absorb UV light or emit fluorescence. It provides a universal detection method with high sensitivity for a broad range of analytes, including those that are invisible to UV detection. The ELS Detector also supports gradient elution, which is essential for the separation of complex mixtures.

3. What types of solvents are compatible with the ACQUITY UPLC ELS Detector?
The ACQUITY UPLC ELS Detector is compatible with a variety of mobile phases commonly used in liquid chromatography. These include water, acetonitrile, methanol, and their mixtures. It is crucial to use high-purity solvents to prevent contamination and ensure accurate and reliable detection. Some additives and buffers may also be used, but it is important to refer to the detector's user manual for specific compatibility and to avoid substances that may cause clogging or interfere with the detection process.

4.Is the ELS Detector compatible with all UPLC systems?
The ACQUITY UPLC ELS Detector is designed to be compatible with Waters UPLC systems, ensuring seamless integration and optimal performance. While it is primarily intended for use with Waters systems, it may also be compatible with other UPLC systems, but this can vary depending on the specific configuration and software used.