Chromatography

Chromatography

Wouldn't you like to know what's in your sample?

Wouldn't you like to know what's in your sample?


Waters lab Immerse Xevo G2-XS QTof No Mask

A chromatography solution designed for what matters to you.


Trade Up Now to the Latest Technologies

Older technology in your lab may be limiting your performance, increasing service costs, and exposing your lab to risk. Let Waters help create a replacement plan that is right for you.



Acquity QDa II Detector With ACQUITY | Scientist in laboratory using pipette

Waters is chromatography.


1963

1963

First GPC introduced:


GPC-100 System



1992

1992

Today's industry standard CDS introduced:


Millennium Software, rebranded in 2002 as Empower Software


1996

1996

Most successful HPLC introduced:


Alliance HPLC System



2004

2004

First sub 2µm LC system introduced:


ACQUITY UPLC System


2021

2021

First LC with HPS introduced:


ACQUITY Premier System



2023

2023

First HPLC built with intuitive simplicity:


Alliance iS HPLC System



Upgrade your system


Scientists across industries rely on Waters to answer the questions that matter, from our intuitive new Alliance iS HPLC System to our range of UHPLC/UPLC, HPLC/UHPLC, HPLC, Purification, and Specialty chromatography systems — all more accessible than ever with our technology renewal program.

We also offer light scattering instrumentation, detectors and pumps and accessories. Not sure which part you’re looking for? Our Product Selection Tools and Resources (including our Graphical Parts Locator) can help.


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Better understand your data


Get the meaningful results you need from our chromatography data system (CDS) and lab management system (LMS) solutions: Empower Software Solutions, NuGenesis Software, and supercritical fluid chromatography (SFC) solution ChromScope Software.

Trust your results


Waters builds quality into everything we do – giving you the confidence you need in your sample preparation and separations workflows. Explore our range of HPLC, UPLC, UHPLC, Bioseparations, GPC/APC, Nano/Micro, Preparative, SFC, or SEC columnsconsumables and lab automation solutions and get the control you need today.


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Get support from a partner you can trust


Waters is here to support you in every step of your chromatography journey, from instrument services and software services to payment solutions to education and training. With Waters as your partner, timely support from a company that knows and understands your lab and goals is never far away.


Application Spotlight: New Modalities


New modality analysis is challenging, but Waters ACQUITY Premier System and ACQUITY Premier Columns and Wyatt MALS detection are helping in the development of molecules ranging from small synthetic oligos to mRNA and AAVs.


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Don’t take our word for it.




Find out what Waters chromatography solutions can do for your lab today.

Find out what Waters chromatography solutions can do for your lab today.

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Chromatography Systems, Detectors, Pumps and Consumables

Waters Corporation, founded on the principle of making a positive impact on customers and society, is a leading global specialist measurement company dedicated to improving human health and well-being through advanced analytical technologies. For over six decades, Waters has been at the forefront of innovation in chromatography, mass spectrometry, and thermal analysis. Their contributions span a wide range of applications, from pharmaceutical discovery to ensuring the safety of food and water supplies, all with the aim of leaving a lasting positive mark on the world and serving the diverse needs of their numerous customers.

Professionals from various sectors trust Waters to address critical inquiries. Our comprehensive lineup, which includes the user-friendly Alliance iS HPLC System and a variety of chromatography systems, is now more accessible through our technology renewal program. In addition to chromatography systems, we provide light scattering instrumentation, detectors, pumps, and accessories. If you're unsure which specific component you need, our Product Selection Tools and Resources, including the Graphical Parts Locator, can assist you in finding the right solution.

A "chromatography solution tailored to your specific needs, covering systems, columns, software, consumables, training, and services" refers to a comprehensive and customized approach to chromatography designed to meet the unique requirements of a user or laboratory. Here's a detailed breakdown of each component:

Systems The term "systems" refers to the chromatography equipment itself, which includes instruments like High-Performance Liquid Chromatography (HPLC) machines. These systems are chosen or configured based on the specific analytical tasks and applications, ensuring they meet the user's technical and operational requirements.

Columns Chromatography columns are a critical component of the system, determining the separation and analysis of compounds. The choice of columns, such as stationary phase chemistry and dimensions, is tailored to the specific compounds and analytes being studied.

Software Chromatography software is used to control the instruments, collect and process data, and analyze results. Customized software solutions can be developed or configured to meet the specific data handling and analysis needs of the user.

Consumables Consumables include items like sample vials, syringes, and other accessories required for sample preparation and analysis. These consumables can be selected to match the specific protocols and requirements of the user's laboratory.

Training Proper training is essential to operate chromatography equipment and software effectively. Customized training programs can be developed to ensure that laboratory personnel are proficient in using the equipment and software to obtain reliable results.

Services Services can encompass a range of offerings, including technical support, maintenance, calibration, and troubleshooting. Customized service agreements can be designed to fit the specific needs of the laboratory, ensuring the chromatography system remains in optimal working condition.

In summary, a chromatography solution tailored to specific needs means that every aspect of the chromatography process, from the choice of equipment to the training and services provided, is customized to meet the exact requirements of the user or laboratory. This ensures that the chromatography process is efficient, reliable, and produces high-quality analytical results for the intended applications.

Chromatography FAQs

1. What is chromatography?
Chromatography is a separation technique used to analyze, identify, and purify components within a mixture. It works by passing the mixture through a medium (the stationary phase) while another substance (the mobile phase) moves through it. Components of the mixture interact differently with the stationary and mobile phases, causing them to separate based on factors like size, charge, or polarity.

Chromatography is widely used in fields such as pharmaceuticals, environmental testing, food safety, and biotechnology to ensure precision in chemical analysis and purification.

2. What is the difference between HPLC, UHPLC, and UPLC?
HPLC (High-Performance Liquid Chromatography), UHPLC (Ultra-High-Performance Liquid Chromatography), and UPLC (Ultra-Performance Liquid Chromatography) are all liquid chromatography techniques, but they differ in terms of performance and efficiency. HPLC operates at lower pressures and is suitable for larger particle sizes, typically 3–5 µm.

UHPLC and UPLC operate at higher pressures, allowing the use of smaller particle sizes (≤2 µm) for better resolution, faster run times, and greater sensitivity. UPLC, a trademark of Waters, is designed specifically for ultra-high pressure and optimized performance, enabling advanced separations with higher throughput compared to traditional HPLC.

3. How do I select the right Waters column for my application?
To choose the right Waters column, consider your specific application requirements, such as the type of analytes, sample matrix, and separation goals. For small molecules, columns like ACQUITY UPLC BEH or CSH are ideal for achieving high resolution and reproducibility. For larger biomolecules, BioSuite or XBridge Protein BEH columns provide excellent separation capabilities. Evaluate particle size, pore size, and stationary phase chemistry to match your workflow, and consider whether you need scalability for analytical or preparative applications.