ACQUITY Arc LC System

ACQUITY Arc System

HPLC and UHPLC method compatibility at the flip of a switch

HPLC and UHPLC method compatibility at the flip of a switch

The ACQUITY Arc System is a quaternary-based, modern LC system for scientists working with established methods who are looking for the versatility and robustness required to bridge the gap between HPLC and UHPLC while continuing to support validated assays.

  • Achieve both HPLC and UHPLC separations in one instrument with regulatory compliant-ready hardware and software 
  • Boost the chromatographic performance of your methods with the benefits of 2.x μm particle columns 
  • Eliminate the cumbersome and error-prone approach of manual preparation with on-demand mobile phase creation with Auto●Blend Plus Technology
  • Adjust for differences in dwell volume between systems to achieve repeatability between systems with the combination of the dual-flow paths and Gradient SmartStart
The ACQUITY Arc System can replicate your established HPLC methods by compensating for these differences with unique features such as the Arc Multi-Flow Path technology and Gradient SmartStart. These innovative attributes enable seamless replication of your existing chromatographic results to meet your acceptance criteria without changes to validated gradient tables. ACQUITY Arc System

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Specifications

Maximum operating pressure  

9500 psi

pH range*  

1–12.5 

Operating flow rate range  

Up to 5 mL/min

Sample flow path   

Stainless-steel

Sample carryover  

≤0.002% (Caffeine) under UV conditions

Sample compartment  

4–40 °C

Pump options  

Quaternary  

Solvent conditioning  

Passive and active pre-heating

Column tracking   

eCord Technology column information tracks and archives column usage

Column capacity

Up to 15 columns of 150 mm length and up to 4.6 mm I.D.

Maximum sample capacity  

Up to 20 plates (with Sample Organizer)

Detector options

TUV Detector

PDA Detector

FLR Detector

RI Detector

ELS Detector

EC Detector

External control   

Empower Software

MassLynx Software

Physical specifications

(QSM-R or BSM-R, SM-FTN-R, 30cm CH)

Width: 34.3 cm (13.5 in.)

Height: 71.1 cm (28.0 in.)

Depth: 71.2 cm (28.0 in.)

Overview

  • Go from HPLC to UHPLC with the flip of a switch - Easily switch between HPLC and UHPLC operation with multi-flow technology to select the dwell volume that fits best the column separation.
  • Simplify your daily set-up - Fully automate your daily system start-up, including system priming and equilibration, with Empower 3 Software. Get real-time information on all of system components in one location, with a simple and intuitive interface using  the ACQUITY Console.
  • Speed mobile phase preparation with more repeatability - Reduce the time it takes to prepare mobile phases while improving the day-to-day repeatability of your preparations by preparing your pH buffers online from pure solvents with Auto●Blend Plus Technology. 
  • Minimize carryover - Achieve ultra-low carryover (≤0.002%) by continuously cleansing the needle during the run with an advanced flow-through-needle design. 
  • Achieve flexibility and stability for method development - Column manager options available for up to 15 columns ranging in length from 50 mm to 300 mm with a temperature range of 4 °C to 90 °C. Optional and integrated column selection valve provide fast, unattended column changeover. 
  • Provide stability for method transfer needs - Provide stable, uniform temperature management with integrated active pre-heating options to ensure method repeatability from lab to lab. Gradient SmartStart easily adjusts for system volume differences when transferring methods from an alternative LC system without alteration to the method table. 

Recommended Use: For modernizing your chromatography while being able to run legacy, validated methods.

Features Header

Features Header

Replicate your established methods

Get seamless and efficient transfer, adjustment, or improvement of methods from any LC platform without compromise in method integrity or changes to validated gradient tables with the ACQUITY Arc System. 

The ACQUITY Arc System can replicate your established HPLC methods by compensating for these differences with unique features such as the Arc multi-flow path technology and Gradient SmartStart. With these innovative attributes, you can seamlessly replicate your existing chromatographic results to meet your acceptance criteria without changes to validated gradient tables.

Go from HPLC to UHPLC with the flip of a switch

With the multi-flow path technology in the ACQUITY Arc System, you can easily switch between HPLC and UHPLC operation by selecting the dwell volume that best fits the column separation. The ACQUITY Arc System’s reliability and robustness ensures product consistency and compliance with regulatory guidelines, all while minimizing downtime and inefficiencies.

With the ACQUITY Arc System, you can maximize productivity by combining system dispersion characteristics with efficient and rapid 2.x µm UHPLC separations or larger, 3.0–5.0 µm particles - so you get the flexibility your lab needs to support a wide-range of LC applications.

Simplify your daily set-up

Improve your laboratory workflow with the advanced software capabilities included with the ACQUITY Arc System.

  • Fully automate your daily system start-up, including system priming and equilibration, with Empower 3 Software.
  • Get real-time information on all of system components in one location with a simple and intuitive interface using  ACQUITY Console.
  • Prepare your pH buffers online from pure solvents, significantly reducing the time it takes to prepare mobile phases while improving the day-to-day repeatability of your preparations with Auto●Blend Plus technology.

Develop methods that stand the test of time

Need an orthogonal detection approach to UV in your method development? Streamline your method development with an LC-MS solution that’s as easy to use as photodiode array detection.

The ACQUITY Arc System is fully compatible with the ACQUITY QDa Mass Detector, supporting efficient and robust method development by expanding the information you can get from your system using the same Empower Software. The system automatically pairs qualitative mass spectral data to the peaks in your chromatogram, leaving nothing to chance.

  • Confirm the identity of peaks in a separation without injecting standards

  • Identify new peaks in a separation with molecular weight information

  • Detect unresolved peaks and determine if a peak is homogenously pure

  • Easily track peaks as method conditions are changed

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ACQUITY Arc LC System

HPLC and UHPLC method compatibility at the flip of a switch

The ACQUITY Arc System is a versatile LC system catering to scientists using established methods, offering a bridge between HPLC and UHPLC. It supports validated assays, providing regulatory-compliant hardware/software, enhanced chromatographic performance using 2.x μm particle columns, and efficient mobile phase preparation with Auto Blend Plus Technology. The system ensures repeatability between systems through dual-flow paths and Gradient SmartStart, enabling both HPLC and UHPLC separations within a single instrument.

Specifications

The ACQUITY Arc System features a maximum operating pressure of 9500 psi, a pH range of 1–12.5, and an operating flow rate range of up to 5 mL/min. It employs a stainless-steel sample flow path, ensuring minimal sample carryover (≤0.002% under UV conditions) and offers a sample compartment temperature range of 4–40 °C. The system supports quaternary pump options, passive and active solvent pre-heating, and utilizes eCord Technology for column tracking. It can accommodate up to 15 columns of 150 mm length and up to 4.6 mm I.D., with a maximum sample capacity of 20 plates using a Sample Organizer. Detector options include TUV, PDA, FLR, RI, ELS, and EC detectors, and it can be controlled via Empower Software or MassLynx Software. The system's physical specifications are a width of 34.3 cm, height of 71.1 cm, and depth of 71.2 cm.

Overview

Effortlessly switch between HPLC and UHPLC using multi-flow tech for optimized column separation. Automate setup with Empower 3 and ACQUITY Console. Improve mobile phase prep with Auto Blend Plus. Minimize carryover (≤0.002%) via advanced needle design. Facilitate method development with up to 15 columns, temp control, and fast changeovers. Ensure transfer stability with pre-heating and Gradient SmartStart. Ideal for modernizing and validated methods.

Replicate your established methods: The ACQUITY Arc System allows smooth method transfer across LC platforms without compromising integrity or altering gradient tables. It utilizes multi-flow path tech and Gradient SmartStart to replicate established HPLC methods accurately, ensuring outcome replication while maintaining validated gradient table integrity.

Go from HPLC to UHPLC with the flip of a switch: The ACQUITY Arc System effortlessly transitions between HPLC and UHPLC modes using multi-flow paths for optimal column separation. It ensures reliability, regulatory compliance, and minimized downtime while enhancing productivity through system dispersion traits and accommodating various LC applications.

Simplify your daily set-up: The ACQUITY Arc System's advanced software includes Empower 3 for automated system start-up, ACQUITY Console for real-time component monitoring, and Auto Blend Plus for efficient online pH buffer generation, enhancing lab workflow.

Develop methods that stand the test of time: The ACQUITY Arc System provides user-friendly LC-MS solutions for UV orthogonal method development. It pairs with ACQUITY QDa Mass Detector, enhancing insights via Empower Software. Mass spectral data is matched to chromatogram peaks, confirming, identifying, and detecting changes without standards for efficient, comprehensive analysis.

FAQs About ACQUITY Arc LC System

1. What types of detectors are compatible with the ACQUITY Arc LC System?
The ACQUITY Arc LC System is compatible with a wide range of detectors, including UV/Vis, photodiode array (PDA), fluorescence, refractive index (RI), evaporative light scattering (ELS), and mass spectrometry (MS) detectors. This compatibility allows for versatile detection options tailored to specific analytical needs.

2. What maintenance is required for the ACQUITY Arc LC System?
Regular maintenance of the ACQUITY Arc LC System includes routine cleaning of the autosampler, degasser, and detectors, as well as checking and replacing pump seals and pistons as needed. It is also important to perform regular calibration and validation to ensure accurate and reliable results. Following the maintenance guidelines and schedule helps to prolong the system's lifespan and maintain optimal performance.

3. What software is used with the ACQUITY Arc LC System?
The ACQUITY Arc LC System is typically operated using Empower Chromatography Data System (CDS) software. Empower software provides comprehensive data management, instrument control, and compliance features, making it suitable for regulated environments. The intuitive interface and powerful data analysis tools facilitate efficient method development, data acquisition, and reporting.

4. What are the benefits of using the ACQUITY Arc System compared to traditional HPLC systems?
The ACQUITY Arc System provides faster analysis times, improved resolution, and higher sensitivity compared to traditional HPLC systems, thanks to its high-pressure capabilities and advanced detector options. It also offers seamless compatibility with established HPLC methods, allowing for easy method transfer without extensive revalidation.