Arc HPLC System

The Waters Arc HPLC System is designed to meet the evolving demands of modern liquid chromatography, providing highly reliable and accurate routine analysis with low complexity. In an environment where regulations continue to shift and tighten, particularly in product quality control, the Arc HPLC System offers the precision and robustness required to meet these stringent standards. With its advanced technology, this system ensures high-efficiency separations and consistent, quality data, helping laboratories maintain compliance with confidence.

One of the key advantages of the Arc HPLC System is its ability to replicate and improve the performance of existing liquid chromatography (LC) methods without compromising data integrity. Many laboratories still rely on older, less efficient HPLC systems that can struggle to meet today"s regulatory requirements. The Arc HPLC System eliminates these inefficiencies, allowing users to easily transfer and enhance existing methods while reducing downtime and the need for extensive method redevelopment. Whether upgrading from a traditional HPLC system or transferring methods from another platform, the Arc HPLC System preserves analyte retention times and reproducibility, ensuring seamless method continuity.

With its rugged and dependable design, the Arc HPLC System strikes the perfect balance between performance and value, making it an excellent choice for labs seeking accurate, first-time analysis and reliable test results. The system is engineered to deliver superior injection precision and low analyte carryover, with high backpressure tolerance that allows it to handle challenging separations with ease. Its flexibility in accommodating various column types and particle sizes makes it suitable for a wide range of analytical applications.

One of the standout features of the Arc HPLC System is its ability to run methods with greater robustness compared to traditional HPLC systems. This enhanced performance translates to fewer errors, improved data accuracy, and faster run times—without the need to redevelop validated methods. The system"s ability to handle higher back pressures also enables users to take advantage of smaller particle size columns, which can significantly improve resolution and reduce analysis time. In side-by-side comparisons with competitive systems, the Arc HPLC System has demonstrated superior peak area repeatability and retention time stability, even at high flow rates.

Additionally, the Arc HPLC System supports compliance with the Empower Chromatography Data System (CDS), a leading compliant-ready software. Empower provides seamless integration with the system, offering intuitive data management and analysis capabilities that ensure adherence to regulatory standards. This makes the Arc HPLC System an excellent solution for industries such as pharmaceuticals, environmental testing, and food safety, where precision and regulatory compliance are paramount.

Meeting strict assay requirements is often a challenge for laboratories, but the Arc HPLC System excels in this area. For instance, in a comparison for the USP assay of losartan potassium, the Arc HPLC System met all system suitability requirements, including injection precision of less than 0.5%. Its performance in USP efficiency, tailing, and injection precision consistently outperforms other HPLC systems on the market. This level of precision makes the Arc HPLC System an ideal choice for labs that require high accuracy in their analyses, particularly when dealing with complex or sensitive assays.

Seamless method transfer is another crucial benefit of the Arc HPLC System. Laboratories can easily transfer methods developed on older systems without the need to modify gradient tables or adjust retention times. This is particularly useful when moving methods between different instruments or laboratories, where method integrity is critical. The Gradient SmartStart feature allows for adjustments in cases where dwell volume differences exist between the sending and receiving systems, ensuring that method transfer is both simple and effective.

The Arc HPLC System"s quaternary gradient formation performs comparably to many binary HPLC systems, especially when handling challenging separations at high flow rates. In direct comparisons, the system demonstrated retention time stability and superior peak area repeatability, making it an excellent option for laboratories that need to maintain high precision under demanding conditions.

The high-pressure capabilities of the Arc HPLC System allow for method scaling using smaller particle columns, which can increase resolution while reducing run times and solvent consumption. In practice, this enables labs to gain more efficiency in their workflows, as shown in comparisons where method scaling from 5 μm to 3.5 μm particles led to improved resolution and faster analysis times. This makes the system a cost-effective solution for labs that need to increase throughput without compromising on performance.

Arc HPLC System FAQs

1. Can I transfer existing HPLC methods to the Arc HPLC System without changing them?
Yes, the Arc HPLC System is designed to allow seamless method transfer from existing HPLC platforms. You can achieve equivalent test results without compromising method integrity or needing to change validated gradient tables. Waters" Gradient SmartStart feature can make adjustments if necessary, ensuring that retention times and method reproducibility remain intact.

2. Can the Arc HPLC System transfer existing methods without redevelopment?
Yes, the Arc HPLC System is designed to seamlessly transfer existing HPLC methods without the need for redevelopment. It replicates the performance of older systems while improving precision and reliability. The system preserves retention times and gradient profiles, ensuring method integrity is maintained. Waters" Gradient SmartStart feature can make minor adjustments to account for differences in dwell volumes between instruments, enabling accurate and reproducible results.

3. How does the system ensure regulatory compliance for stringent applications?
The Arc HPLC System is engineered to meet evolving regulatory requirements by delivering precise, reliable, and repeatable results. It supports compliance with established guidelines, including those outlined by the United States Pharmacopeia (USP) and other regulatory bodies. Additionally, the system integrates with the Empower Chromatography Data System (CDS), which provides secure data handling, electronic signatures, and audit trails to ensure adherence to compliance standards like FDA 21 CFR Part 11. These features make the system ideal for industries requiring strict regulatory oversight, such as pharmaceuticals and environmental testing.

4. What is Gradient SmartStart?
Gradient SmartStart is a feature of the Arc HPLC System that addresses dwell volume differences between instruments when transferring methods. By adjusting the gradient start time, the feature ensures that retention times and gradient profiles remain consistent across platforms. This simplifies method transfer between different HPLC systems without compromising analyte resolution or reproducibility. Gradient SmartStart eliminates the need for complex recalibration or method redevelopment, saving time and ensuring seamless adoption of methods across laboratories or instruments.

5. What types of columns and detectors are compatible with the Arc HPLC System?
The Arc HPLC System is compatible with a wide range of Waters columns and detectors to accommodate diverse analytical needs. It supports columns with particle sizes as small as 3.5 µm for high-efficiency separations and can handle column dimensions up to 7.8 mm ID and 300 mm in length. Compatible detectors include Tunable UV/Vis (TUV), Photodiode Array (PDA), Fluorescence (FLR), Refractive Index (RI), Evaporative Light Scattering (ELSD), Conductivity (CD), Electrochemical (ECD), and the ACQUITY QDa Mass Detector (QDa).