Arc Premier LC System

Arc Premier System

See clearly and consistently, with confidence.

See clearly and consistently, with confidence.

Today’s scientists and lab managers need to confidently produce the most accurate, reliable, and reproducible data. The Arc Premier System produces correct, robust results from the very first injection, reliably and easily. 

The Arc Premier System features the new, innovative solution of MaxPeak High Performance Surfaces (HPS) Technology, which effectively reduces non-specific adsorption due to metal interaction — without complicated mobile phases or laborious methods. The Arc Premier System sharpens chromatographic peaks for metal-sensitive compounds by eliminating secondary interactions from metals, so you can:

  • Support meeting compliance standards with higher quality data
  • Achieve faster, more reproducible, and accurate data integration
  • Shorten time from sample to result by eliminating the need for system conditioning
Designed with MaxPeak HPS technology and paired with MaxPeak Premier 2.5 µm Columns, the Arc Premier System improves data quality for challenging compounds. Arc Premier System

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Specifications

Maximum operating pressure

9500 psi

pH range*

1 to 12.5 

Operating flow rate range

Up to 5 mL/min

Sample flow path 

Inert (MaxPeak HPS Technology)

Sample carryover

<0.002% (Caffeine) under UV conditions

Sample compartment

4 to 40 °C

Pump options

Binary, Quaternary

Solvent conditioning

Active pre-heating

Passive pre-heating

Column tracking 

eCord Technology column information tracks and archives column usage

Column capacity

Up to 6 columns of 150 mm length and up to 4.6 mm I.D.

Maximum sample capacity

Up to 20 plates (with Sample Organizer)

Detector options

TUV Detector

PDA Detector

FLR Detector

RI Detector

ELS Detector

External control

Empower Software

MassLynx Software

Physical specifications

(QSM-R or BSM-R, SM-FTN-R, CHA)

Width: 34.3 cm (13.5 in.)

Height: 71.1 cm (28.0 in.)

Depth: 71.2 cm (28.0 in.)

* For specific test conditions, contact your Waters sales representative

Overview

  • See your sample clearly - Get the full picture of your sample with MaxPeak HPS Technology, which provides up to 10x improvements in assay-to-assay precision, up to 5x improvements in sensitivity, and 30% faster data processing for metal sensitive compounds.
  • Flexibly blend multiple solvents - Blend from four up to nine solvents in any combination or proportion with multi-solvent blending with the Quaternary Solvent Manager (QSM). Blend accurately at a constant pressure of up to 9500 psi throughout the flow rate range with the Binary Solvent Manager (BSM-R).
  • Get high-precision injections with direct inject sampling - The needle-in-flow path design ensures an accurate needle seal at high pressure for injection volumes from 0.1 μL up to 1 mL. Achieve ultra-low carryover (≤0.002%) through programmable method settings – for compatibility with even the most sensitive mass spectrometers.
  • Achieve flexible, stable method development - Accommodate up to six columns ranging in length from 50 mm to 300 mm with a temperature range of 4 °C to 90 °C, with column manager options and optional and integrated column selection valves for fast, unattended column changeover. 
  • Ensure stability for method transfers - Ensure method repeatability from lab to lab with stable, uniform temperature management with integrated active pre-heating options. Gradient SmartStart easily adjusts for system volume differences when transferring methods from an alternative LC system without alteration to the method table.
  • Eliminate manual, error-prone mobile phase solution preparation - Directly program gradients in units of pH and ionic strength with Auto●Blend Plus Technology to vary composition in the smallest increments of pH, improve day-to-day repeatability, and eliminate time-consuming manual mobile phase solution preparation.

Recommended Use: For improving the peak shape and reproducibility of even the most challenging metal-sensitive compounds.

Features Header

Features Header

Gain control of the unpredictable

Non-specific adsorption of metal sensitive compounds is an unpredictable challenge, resulting in chromatography with large relative standard deviations (RSDs) and broad, overlapping peaks, which can be challenging to integrate quickly and be accurate consistently.

Designed with MaxPeak HPS technology and paired with MaxPeak Premier 2.5 um columns, the Arc Premier System improves data quality for challenging compounds, including metal-sensitive compounds tested with LC methods – so you can see clearly and consistently, with confidence.

Future-proof your lab for the next challenging compounds

Data quality and performance are critical for your lab, but those can’t come at the sacrifice of ruggedness and ease of use. Now you can future-proof your lab for the next generation of challenging compounds with MaxPeak HPS Technology, which sharpens peaks for metal-sensitive compounds for higher data quality and improved sensitivity with chromatographic reproducibility and precision. With MaxPeak HPS Technology and flexible LC performance, your lab gets the typical benefits of an LC system optimized for 2.5 – 3.5 µm column chemistry with the ability to shorten run times and achieve sharp peaks—no lengthy and complex conditioning and conditioning methodologies for metal-sensitive compounds required.

Reduce analytical uncertainty and achieve peace of mind

With MaxPeak HPS Technology, metal-sensitive analytes become visible that were previously undetectable. This allows you to quickly and confidently know that you've seen everything in your sample, giving you the confidence to stand behind your data-driven decisions. The combination of MaxPeak HPS Technology, flexible pump and column management options, and precise optical and MS detection give you the method development and verification capabilities to know that no matter the sample – you can deliver a robust method you can stand behind.

By eliminating the need for time-consuming system passivation, your organization can both decrease the time to obtain results as well as reduce excessive mobile phase consumption. This gives your laboratory more confidence in meeting timeline, budgetary, and sustainability goals.

Reduce user errors, compliance issues, and expensive audits

With MaxPeak HPS Technology, metal-sensitive analytes become visible that were previously undetectable. This allows you to quickly and confidently know that you've seen everything in your sample, giving you the confidence to stand behind your data-driven decisions. The combination of MaxPeak HPS Technology, flexible pump and column management options, and precise optical and MS detection give you the method development and verification capabilities to know that no matter the sample – you can deliver a robust method you can stand behind.

By eliminating the need for time-consuming and error prone system passivation or conditioning that can introduce system-to-system variability, your organization can decrease the time to obtain results, excessive mobile phase consumption, and method transfer data repeatability problems. This gives your laboratory more confidence in meeting timeline, budgetary, and sustainability goals.

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Arc Premier LC System

The Arc Premier System is a groundbreaking solution for scientists and lab managers who want to achieve the highest standards of data accuracy, reliability, and reproducibility. With MaxPeak High Performance Surfaces (HPS) Technology, this system addresses the critical issue of non-specific adsorption due to metal interactions, streamlining the process without the need for complex mobile phases or extensive method development. By eliminating secondary interactions from metals, the Arc Premier System ensures enhanced chromatographic peak sharpness for metal-sensitive compounds, facilitating compliance with quality standards and enabling faster, more accurate data integration.

Key features include up to tenfold improvements in assay precision and a fivefold increase in sensitivity, alongside a 30% boost in data processing speed for metal-sensitive compounds. The system's versatility is highlighted through its multi-solvent blending capabilities, ranging from four to nine solvents, and its high-precision injection volumes ranging from 0.1 μL to 1 mL, all supported by ultra-low carryover rates (≤0.002%) for compatibility with sensitive mass spectrometers.

Additionally, the Arc Premier System offers flexible method development with options for up to six columns and integrated column selection valves for rapid changeovers. Stability is ensured across lab environments with uniform temperature management and gradient SmartStart for seamless method transfers. The innovative Auto-Blend Plus Technology further revolutionizes mobile phase preparation by programming gradients in units of pH and ionic strength, significantly reducing manual labor and potential errors. Designed for the most challenging metal-sensitive compounds, the Arc Premier System is the ideal choice for laboratories seeking to elevate their analytical capabilities.

Arc Premier LC System FAQs

1.How does the Arc Premier LC System improve upon previous LC systems?
The Arc Premier LC System offers several key improvements over previous LC models, particularly in terms of precision, reliability, and data quality. One of its standout features is MaxPeak High-Performance Surfaces (HPS) technology, which minimizes analyte interactions with metal surfaces, leading to better peak shape and recovery for metal-sensitive compounds.
The system also offers enhanced sensitivity and resolution, making it ideal for complex analyses. Additionally, the Arc Premier system is designed with user-friendly software and improved automation capabilities, streamlining workflows and reducing the potential for errors in data collection and analysis.

2.What is MaxPeak HPS Technology, and how does it benefit the Arc Premier LC System?
MaxPeak High-Performance Surfaces (HPS) Technology is a breakthrough feature in the Arc Premier LC System that minimizes unwanted interactions between analytes and metal surfaces within the system. This technology is particularly beneficial for the analysis of metal-sensitive compounds, such as phosphates, carbohydrates, and acidic proteins, which can be absorbed or degraded by traditional metal surfaces.
By reducing these interactions, MaxPeak HPS ensures better peak shape, improved recovery, and more accurate quantitation. This results in higher-quality data, greater reproducibility, and enhanced confidence in the analytical results obtained from the system.

3. What software is compatible with the Arc Premier LC System for data analysis?
The Arc Premier LC System is compatible with Waters' Empower Software, a powerful and versatile platform for data acquisition, processing, and reporting. Empower Software is designed to handle complex workflows and large datasets, offering features like automated peak detection, integration, and advanced reporting tools.
The software also supports compliance with regulatory requirements, making it suitable for use in regulated environments. Empower Software provides seamless integration with other laboratory systems and instruments, enhancing overall lab efficiency and ensuring that data management is streamlined and secure throughout the entire analytical process.