HPLC/UHPLC Systems
Waters' HPLC and UHPLC systems set the standard for reliable, high-performance liquid chromatography, empowering laboratories to achieve precise separations, reproducible results, and exceptional efficiency across a wide range of applications. Designed to meet the diverse needs of modern analytical workflows, these systems offer unparalleled performance, flexibility, and robustness to support both routine analysis and advanced research.
HPLC (High-Performance Liquid Chromatography) and UHPLC (Ultra-High-Performance Liquid Chromatography) systems from Waters are ideal for applications in pharmaceutical development, environmental testing, food safety, biopharmaceutical characterization, and clinical research. Whether performing routine quality control or complex method development, these systems provide the accuracy and sensitivity required to meet regulatory and scientific demands.
With Waters' advanced system configurations, users can achieve exceptional resolution and reproducibility for the separation and analysis of small molecules, biomolecules, and challenging sample matrices. The systems are engineered for precision, enabling laboratories to confidently identify, quantify, and characterize analytes, even in trace-level concentrations.
Waters' HPLC and UHPLC systems incorporate cutting-edge technologies to enhance productivity and efficiency. Features such as automated sample handling, advanced solvent management, and precise temperature control enable seamless integration into workflows, reducing operator intervention and minimizing errors. Ultra-low dispersion and optimized flow paths ensure peak performance, delivering sharp, well-defined chromatographic separations.
The systems are compatible with a wide range of detectors, including UV/Vis, fluorescence, refractive index, and mass spectrometry, offering flexibility for various analytical needs. Waters' column chemistries, including BEH, CSH, and HSS, are specifically designed to complement HPLC and UHPLC systems, providing unmatched retention, selectivity, and durability.
Waters' chromatography systems are supported by user-friendly software solutions, such as Empower and MassLynx, which streamline data acquisition, processing, and reporting. These platforms provide intuitive interfaces and advanced tools for method development, compliance with regulatory requirements, and data integrity. Empower's scalability accommodates laboratories of all sizes, while MassLynx excels in integrating LC-MS workflows, making the systems versatile and adaptable to evolving laboratory needs.
Waters HPLC and UHPLC systems are built for long-term reliability, ensuring consistent performance under demanding conditions. Advanced engineering minimizes system downtime, reduces maintenance requirements, and extends the lifespan of critical components. Additionally, energy-efficient designs and reduced solvent consumption align with sustainability goals, lowering the environmental impact and operational costs.
From routine analysis to cutting-edge research, Waters offers a range of HPLC and UHPLC configurations tailored to your laboratory's specific needs. Whether you require traditional HPLC for established methods or the advanced capabilities of UHPLC for faster, higher-resolution separations, Waters has a solution to match your workflow.
Waters HPLC and UHPLC systems combine precision, innovation, and reliability to advance laboratory capabilities. With robust hardware, intuitive software, and a commitment to sustainability, these systems empower scientists to tackle analytical challenges with confidence, delivering consistent, high-quality results every time.
FAQ
1. What is the difference between HPLC and UHPLC systems?
HPLC (High-Performance Liquid Chromatography) and UHPLC (Ultra-High-Performance Liquid Chromatography) systems differ primarily in their operating pressures, particle sizes, and separation efficiencies. HPLC systems typically use larger particle sizes (3–5 µm) and operate at pressures up to 6,000 psi, making them suitable for traditional chromatography workflows.
UHPLC systems, such as Waters ACQUITY UPLC, operate at much higher pressures (up to 15,000 psi) and use smaller particle sizes (sub-2 µm), resulting in faster run times, higher resolution, and greater sensitivity. UHPLC systems are ideal for labs needing higher throughput and better performance for complex or trace-level analyses.
2. How do I choose the right Waters system for my laboratory's needs?
Choosing the right Waters system depends on your laboratory's specific requirements, such as the complexity of your samples, throughput needs, and available budget. For routine analyses and established workflows, HPLC systems provide reliable performance and cost efficiency. For advanced applications requiring faster separations, higher sensitivity, and improved resolution, UHPLC systems like Waters ACQUITY UPLC are a better fit.
Consider factors like compatibility with existing detectors, column preferences, and integration with software platforms like Empower or MassLynx. Waters' experts and resources can also help guide you toward the best system for your goals and workflows.
3. What applications are Waters HPLC and UHPLC systems best suited for?
In pharmaceutical development, these systems are essential for tasks such as routine quality control, impurity profiling, stability studies, and method development for small molecules and active pharmaceutical ingredients (APIs). For biopharmaceutical characterization, they provide precise analysis of proteins, peptides, and monoclonal antibodies (mAbs), including glycan profiling and intact mass analysis.
In the food and beverage industry, Waters' systems are used to detect contaminants, ensure the quality of food additives, and perform nutrient analysis. Environmental analysis is another key application area, where these systems are used to monitor pollutants, pesticides, and trace organic compounds in water, soil, and air samples.
In clinical research, HPLC and UHPLC systems are widely employed for the quantification of biomarkers, drug metabolites, and therapeutic compounds in biological matrices.
Additionally, these systems are indispensable in academic and industrial research, where they enable advanced method development, compound identification, and molecular characterization.
