LC Prep 150 System

LC Prep 150 System

A versatile system to suit your purification requirements 

A versatile system to suit your purification requirements 

The LC Prep 150 System is a fit-for-purpose solution designed for scientists requiring robust system performance with intuitive software for dedicated personal purification or quick adoption in centralized labs.

Ideal for workflows where rapid separations of complex mixtures are required, this versatile system is designed to satisfy your application requirements, whether you are processing a few samples a day, or your workload demands greater throughput with unattended automation. With the LC Prep 150 System, your lab can rapidly process your valuable complex mixtures—resulting in high purity and recovery with complete confidence.

LC Prep 150 System LC Prep 150 System

Specifications

Operating flow rate range

Programmable from 0 to 150 mL/min, in 0.01 increments

Operating pressure range

5000 psi (345 bar)

Supported column dimensions

10, 19, 30, and 50 mm I.D.

Wetted material

316 stainless steel, UHMWPE, sapphire, ruby, Tefzel (ETFE), Teflon (FEP, PTFE, FPA), nitronic 60, vlacon H, chemraz, and PEEK

Software

ChromScope

*Individual component specifications may allow operation outside the total system defined parameters. The system is designed and tested only for the ranges defined in system specifications. 

2545 Binary System

2545 Quaternary System

Dwell volume

≤350 μL

<6.5 mL

Flow accuracy

±1.0% of required flow or

10 μL/min, whichever is greater

(MeOH or water at 600 psi)

±1.0% of required flow

(MeOH or water at 600 psi)

Composition accuracy

±1.0% of required flow or

5% to 95%, and from 1 to 150 mL

(MeOH or water step gradients)

±3% absolute (full scale) from

5% to 95%, and from 1 to 150 mL/min

(MeOH or water step gradients) at 600 psi

Composition precision

Retention time variation <0.3% RSD or

0.1 min SD, whichever is greater (dial-a-mix, uracil/caffeine, 6 replicates, 1, 20, 50 mL/min, 70:30 water/MeOH)

Retention time variation <0.15 min SD, (dial-a-mix uracil/caffeine; 1, 5, 20, 50, 150 mL/min; 70:30 water/MeOH)

Number of solvents

Up to four: A1 or A2, B1 or B2

Up to four selectable. 0% to 100% programmable in .01% increments for each reservoir

Gradient composition curves

Eleven (11) gradient curves including linear (1), step (2), concave (4), and convex (4)

Compressibility compensation

Automatic and continuous

Pump seal wash

Integral, active, programmable

Priming

Self-prime from solvent container on floor with dry lines

Collection capacity

Standard test tube (13.0 to 18.0 mm) rack (120 tubes)

Eppendorf tube rack (120 tubes)

Scintillation vial (16.5 mm) rack (120 vials)

Scintillation vial (27.5 mm) rack (56 vials)

Microtiter plate rack (4 x 96/384)

Preparative funnel rack (4 x 32 positions)

Multipurpose rack

Injector

3725i continuous flow design (MBB)

Injectors

7725i analytical continuous flow design (MMB)

3725i continuous flow design (MMB)

Injection volume

0 to 10,000 μL in 1 μL increments

Sample loop volume

10 mL sample loop

Sample capacity

Two 12-vial trays for 10 mL vials

Syringe size

2.5 mL

Voltage

100 to 240 VAC

Frequency

50 to 60 Hz

Manual

Width: 71 cm (28 inches)

Height: 64 cm (25 inches)

Depth: 64 cm (25 inches)

Prep 150Q LC w/TUV

Weight: 60 kg (132 pounds)

Prep 150B LC w/TUV

Weight: 78 kg (171 pounds)

Prep 150Q LC w/PDA

Weight: 63 kg (140 pounds)

Prep 150B LC w/PDA

Weight: 80 kg (177 pounds)

Automated

Width: 86 cm (34 inches)

Height: 64 cm (25 inches)

Depth: 64 cm (25 inches)

Prep 150Q LC w/TUV

Weight: 75 kg (165 pounds)

Prep 150B LC w/TUV

Weight: 93 kg (205 pounds)

Prep 150Q LC w/PDA

Weight: 78 kg (172 pounds)

Prep 150B LC w/PDA

Weight: 95 kg (209 pounds)

Overview

  • Ideally suited for initial workflow criteria requiring rapid preparative separations of complex mixtures
  • Robust system performance with intuitive ChromScope Software
  • Rapidly process your complex mixtures with complete confidence

Recommended Use: Ideal for dedicated personal purification or quick adoption in centralized labs with robust system performance and intuitive software.


Features Header

Features Header






Purification, made simple

The Waters LC Prep 150 System and ChromScope Software make purification simple. Meet your laboratory’s purification needs with the LC Prep 150 System, including options like:

  • Flexible solvent delivery options, including binary or quaternary based pumps for low-pressure multi-solvent blending or high-pressure gradient mixing of flow rates up to 150 ml/min
  • Easy to use manual or automated sample injection options for the versatility to accommodate a wide range of workload requirements
  • Highly sensitive detectors, enabling you to identify and isolate compounds of interest with enhanced linear range to accommodate highly concentrated samples
  • A reliable easy-to-use fraction collector for highly precise sample collection, with flexible collection racks and vessel options accommodating a variety of fraction sizes
  • Easy-to-navigate ChromScope Software, delivered with sample set wizard, stacked injection wizard, key fraction collection parameters, fraction simulation modeling, and customizable reporting with drop and drag features.
  • Internal column diameters of up to 50 mm, to confidently purify sample loads of milligrams to grams 




Resources

Documents

Documents


Support

Support



Related

ChromScope Software is for use on Waters supercritical fluid chromatography (SFC) and liquid chromatography (LC) purification systems. It enables fully automated instrument control, SFC methods development, and sample purification.

Achieve fast, efficient, lab-scale separations, and greater throughput with Waters Preparative HPLC Columns, which provide predictable performance and easily scale from analytical to prep.

Protect your Waters LC or LC-MS system investment and ensure optimum productivity and compliance with the range of plans in FlexCHOICE Instrument Service Coverage.
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LC Prep 150 System

The Waters LC Prep 150 System is a versatile and reliable solution designed to meet the diverse purification needs of laboratories and researchers. Whether used for personal purification workflows or integrated into centralized lab environments, this system combines robust performance with intuitive operation to deliver high-quality results efficiently. It is ideal for workflows requiring the rapid separation of complex mixtures, ensuring consistent high-purity and high-recovery outcomes that you can trust. This flexibility makes it suitable for labs handling small daily workloads or demanding high-throughput processes with unattended automation.

Built to adapt to various purification requirements, the LC Prep 150 System offers advanced solvent delivery capabilities. With the option of binary or quaternary pumps, the system supports low-pressure multi-solvent blending and high-pressure gradient mixing, accommodating flow rates of up to 150 mL/min. These options provide scientists with precise control over their purification processes, enabling them to achieve accurate and reliable results. The system"s manual and automated sample injection options ensure that it can accommodate a wide range of workload demands, from small-scale purification tasks to larger-scale projects requiring continuous operation.

Sensitive detection capabilities are at the heart of the LC Prep 150 System. With enhanced linear range, the detectors allow for accurate identification and isolation of compounds of interest, even in highly concentrated samples. The fraction collection system further enhances the system"s functionality, offering precision in sample collection. Flexible racks and vessel options allow for a variety of fraction sizes, ensuring the system meets the unique needs of your workflow.

The LC Prep 150 System is powered by ChromScope Software, a user-friendly platform designed to simplify the purification process. Its intuitive interface provides tools such as the sample set wizard and stacked injection wizard, which streamline method setup and operation. Fraction simulation modeling allows you to optimize collection parameters without consuming valuable samples, maximizing both efficiency and cost-effectiveness. Additionally, the software offers customizable reporting capabilities with drag-and-drop functionality, ensuring that your documentation is clear, professional, and tailored to your specific requirements.

Engineered for high performance, the LC Prep 150 System accommodates internal column diameters of up to 50 mm. This capacity supports the purification of sample loads ranging from milligrams to grams, making it suitable for a wide range of preparative applications. Its ability to deliver rapid, reliable separations of complex mixtures makes it an indispensable tool for laboratories looking to enhance their purification capabilities.

Designed for ease of use and robust performance, the LC Prep 150 System offers laboratories the flexibility, precision, and confidence needed to meet their purification goals. Its seamless combination of advanced hardware and intuitive software enables scientists to process complex mixtures efficiently, saving valuable time while achieving superior results. Whether you"re developing initial workflows or managing high-throughput operations, the LC Prep 150 System is the ideal choice for consistent, high-quality purification.

Let the LC Prep 150 System elevate your lab"s performance and redefine your approach to purification, providing a streamlined solution that prioritizes accuracy, reliability, and simplicity.

FAQs about LC Prep 150 System

What is the LC Prep 150 System?
The LC Prep 150 System is a high-performance liquid chromatography system designed to provide fast, reliable, and reproducible results. It is ideal for sample preparation and analysis of complex samples.

What are the features of the LC Prep 150 System?
The LC Prep 150 System features a high-pressure gradient pump, a low-pressure mixing valve, a high-resolution UV detector, and a high-performance autosampler. It also has a user-friendly software interface and a range of accessories for sample preparation and analysis.

What types of samples can be analyzed with the LC Prep 150 System?
The LC Prep 150 System can be used to analyze a wide range of samples, including proteins, peptides, carbohydrates, lipids, and small molecules.

What is the maximum pressure of the LC Prep 150 System?
The maximum pressure of the LC Prep 150 System is up to 600 bar (8700 psi).

What is the warranty for the LC Prep 150 System?
The LC Prep 150 System comes with a one-year warranty.