PATROL UPLC Process Analysis System

PATROL UPLC Process Analysis System

Take control of your bottom line with real-time LC

Take control of your bottom line with real-time LC

Process development laboratories are challenged to modernize scientific processes that ensure final product quality and improve process yields. One of the critical components is process analytical technology (PAT), where timely quantitative measurements are taken throughout production to measure Critical Quality Attributes (CQA). 

With Waters, in-process decisions can rely on streaming CQA feedback. The PATROL UPLC Process Analysis System provides access to real-time, chromatographic-quality analysis for in-process samples. This PAT tool gives you streaming CQA feedback, aligning UPLC technology with Quality by Design (QbD) principles in your process development laboratory.

PATROL UPLC Process Analysis System PATROL UPLC Process Analysis System

Overview

  • Ensure final product quality and improve process yields

  • Work with real-time information that provides a great understanding of the efficiency and quality of your processes

  • Achieve best-in-class analyses designed specifically for in-process analysis

  • Rely on results that improve operational efficiency, deliver quantifiable ROI, and increase profits

Recommended Use: Designed for in-process analysis, delivering simultaneous qualitative, and quantitative information. 

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Take control of your process

The PATROL UPLC Process Analysis System is specifically designed for in-process analysis, delivering simultaneous qualitative and quantitative information and allowing you to dynamically adjust and control your process. Gain confidence that your process is under control and within design space with continuous system uptime and remote access from any location.

Improve your bottom line

Rely on results that improve operational efficiency, deliver quantifiable return on investment (ROI), and increase profits with the PATROL UPLC Process Analysis System.

The system will help your lab increase process recoveries and yields, improve brand integrity with quality improvements and faster delivery, boost consumer satisfaction, and improve process understanding. With the PATROL UPLC Process Analysis System, your lab can reduce process cycle times, process and product variability, product rework, and bottlenecks.

Overcome process challenges with UPLC

Spectroscopic technology may provide real-time identity information about processes, but it lacks the ability to simultaneously monitor multiple components at different levels, and does not provide the quantitative analysis, sensitivity, linearity/dynamic range, and resolution that ultra-performance liquid chromatography (UPLC/UHPLC) provides.

The PATROL UPLC Process Analysis System provides a fast and easy-to-use method that generates real-time data, filling the gap where the slower HPLC technique has traditionally come up short as the online and automated analytical tool desired by process chemists.

 

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PATROL UPLC Process Analysis System

The PATROL UPLC Process Analysis System from Waters Corporation stands as a cornerstone in modern process development laboratories, designed to elevate the precision and efficiency of in-process analysis. This system is a pivotal component of process analytical technology (PAT), providing real-time, chromatographic-quality data essential for monitoring Critical Quality Attributes (CQA) and ensuring the alignment of Ultra-Performance Liquid Chromatography (UPLC) technology with Quality by Design (QbD) principles.

The core of the PATROL UPLC system is high-pressure HPLC pumps that deliver precise and consistent flow rates, which are critical for accurate sample separation and analysis. Coupled with an automated autosampler, the system minimizes human error and maximizes throughput by facilitating automated sample injections, enhancing both efficiency and reliability. The chromatographic column within the controlled temperature compartment ensures optimal separation efficiency and reproducibility, leading to consistent analytical results.

Detection capabilities are robust, featuring sensitive detectors such as UV-Vis, fluorescence, or mass spectrometry options that cater to a range of analytical needs. These detectors are integral for achieving high sensitivity and selectivity in quantifying analytes, thereby upholding stringent quality standards.

One of the unique benefits of the PATROL UPLC Process Analysis System is its ability to bridge the gap left by slower traditional HPLC techniques, providing a faster and more reliable method for real-time data generation. This capability is crucial for process chemists who require an online and automated analytical tool that not only speeds up the analysis but also enhances process control.

The inclusion of sophisticated data management software is another key aspect, supporting efficient data acquisition, processing, and interpretation. This software aids in seamless reporting and ensures compliance with regulatory standards, including 21 CFR Part 11 for electronic records and signatures. The system"s modular design allows for customization and scalability, making it adaptable to various applications and industry-specific requirements.

By integrating the PATROL UPLC System into their operations, laboratories can significantly improve process yields and final product quality. The system helps reduce process cycle times, variability, and bottlenecks while minimizing product rework. This leads to enhanced operational efficiency, quantifiable return on investment, and increased profits, all while ensuring that processes remain within designed control limits.

Additionally, the system"s ability to provide simultaneous qualitative and quantitative information allows for dynamic adjustments in the manufacturing process, ensuring that the production is always aligned with predefined quality parameters. This real-time capability is vital for maintaining brand integrity, boosting consumer satisfaction, and enhancing overall process understanding.

The PATROL UPLC Process Analysis System by Waters offers a comprehensive solution for achieving higher productivity, ensuring product quality, and maintaining regulatory compliance. It is an essential tool for any process development laboratory committed to modernizing and optimizing its scientific processes.