SFC Prep 150 AP System

SFC Prep 150 AP System

Designed for automated UV and/or MS-triggered purification

Designed for automated UV and/or MS-triggered purification

The SFC Prep 150 AP System is the first and only commercially available preparative SFC system offering automated sample handling, column switching, fraction collection and tracking in an easy-to-use, open bed format.

The SFC Prep 150 AP System provides routine compound purification for drug discovery labs using the MassLynx Software with FractionLynx Application Manager, offering fast separations, high resolution, and high throughput. The inherent benefits of SFC, combined with Waters’ world-renowned service and support provides users with a robust, cost-effective solution to any purification lab.

SFC Prep 150 AP System. SFC Prep 150 AP System

Specifications

Overview

  • Offers automated sample handling, column switching, fraction collection, and tracking in an easy-to-use, open bed format
  • Achieve fast separations, high resolution, and high throughput
  • Attain routine compound purification for drug discovery labs, using the Waters MassLynx/FractionLynx Application Manager
  • Benefit from a robust, cost-effective solution to any purification lab, when combined with world-renowned service and support from Waters

Recommended Use: For drug discovery labs needing fast separations, high resolution, and high throughput in routine compound purification.


Features Header

Features Header






Automate the purification process

The SFC Prep 150 AP System automates the purification process by linking analytical pre-screen, purification and fraction re-analysis with AutoPurify in an “open access” setting.

SFC systems utilize liquid carbon dioxide (CO2) as its main mobile phase in combination with one or more organic solvents resulting in faster equilibration, lower pressure drops across the column, solvent reduction, and decreased cost per sample. The process is reproducible and applicable to a wide range of compounds relevant in the pharmaceutical, life sciences, chemical materials, food, and environmental markets.


Moving SFC forward

The SFC Prep 150 AP System comes equipped with modules to help with routine compound purification, including:

  • QGM Low Pressure mixing Quaternary Gradient Pump: This pump delivers flowrates up to a maximum of 150 mL/min as serves as the co-solvent delivery device for this system.
  • P200X CO2 Pump: This is a high-pressure delivery pump having dual stainless-steel heads with a cam driven sapphire piston assembly; self-priming check valves; presser sensor; pressure gauge; brushless motor; and a rupture disc assembly. The pumps design lends itself to control based upon feedback from the pressure sensor and mass flowmeter.
  • 3767 Sample Manager: This module provides injection and collection capability in an open bed format. The system includes the fume hood assembly for the 3767 for CO2 management. Injection and collection racks must be ordered for the system. The specific racks required will be determined by your needs and requirements.
  • Analytical-2-Prep Column Oven: A thermal control module, the Analytical-2-Prep Column Oven's unique drawer design gives the user unprecedented flexibility, enabling the use of 10 mm, and 20 mm diameter columns simultaneously.

Optional modifier stream injection

The Modifier Stream Injector’s function is to inject one sample at a time directly into the co-solvent flow. This device allows for settable air gaps on either side of the sample, which function as a buffer between the solvent and the sample decreasing dilution. There are two benefits to the MSI:

  • The sample is injected into the organic portion of the mobile phase (co-solvent) prior to mixing with CO2. The idea is to mitigate the diluent affect by introducing the sample without affecting the overall strength of the mobile phase, and maintaining the programmed solvent percentages throughout the injection and run. Modifier-stream injection provides improved peak shape and resolution, allowing for larger injection volumes, and higher loading (image 1).
  • It allows for Stacked Injections. Stacked injections reduce the time between injection cycles and minimize solvent usage. Stacked injections also significantly improve throughput by utilizing all of the available chromatographic space for continuous separation and purification. Usually, injections are made while an already injected sample is on (or eluting from) the column (image 2).


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SFC Prep 150 AP System

The SFC Prep 150 AP System is a groundbreaking preparative supercritical fluid chromatography (SFC) system designed to revolutionize compound purification in drug discovery labs. As the first and only commercially available system offering automated UV and/or MS-triggered purification, it integrates advanced automation features such as sample handling, column switching, fraction collection, and tracking in an easy-to-use open bed format.

Achieve unparalleled fast separations, high resolution, and high throughput with the SFC Prep 150 AP System, making it an essential tool for routine compound purification. The system's capabilities are enhanced by the MassLynx Software with FractionLynx Application Manager, ensuring seamless operation and efficient workflow management. The benefits of SFC, combined with Waters' renowned service and support, provide users with a robust, cost-effective solution tailored to the demanding needs of any purification lab.

The SFC Prep 150 AP System automates the purification process by linking analytical pre-screening, purification, and fraction re-analysis with AutoPurify in an open access setting. Researchers can utilize liquid carbon dioxide (CO2) as the main mobile phase in combination with organic solvents; the system ensures faster equilibration, lower pressure drops across the column, reduced solvent consumption, and decreased cost per sample. This reproducible process is applicable to a wide range of compounds relevant to pharmaceutical, life sciences, chemical materials, food, and environmental markets.

Equipped with state-of-the-art modules, the SFC Prep 150 AP System facilitates routine compound purification with precision. These include:

An optional Modifier Stream Injector (MSI) enhances the system's performance by injecting samples directly into the co-solvent flow, reducing dilution, and maintaining solvent strength throughout the injection and run. This feature allows for larger injection volumes and higher loading, resulting in improved peak shape and resolution. The MSI also supports stacked injections, reducing the time between injection cycles and minimizing solvent usage. This significantly improves throughput by utilizing all available chromatographic space for continuous separation and purification.

The SFC Prep 150 AP System represents a significant advancement in preparative SFC technology. With its comprehensive automation, high throughput capabilities, and flexible module options, it is the ideal solution for drug discovery labs requiring efficient and reliable compound purification. Waters continues to lead the industry with innovative chromatography solutions, and the SFC Prep 150 AP System is a testament to its commitment to excellence in analytical science.

FAQs about SFC Prep 150 AP System

What is the SFC Prep 150 AP System?
The SFC Prep 150 AP System is a high-performance preparative supercritical fluid chromatography (SFC) system designed to provide fast, reliable, and reproducible separations of complex samples.

What are the benefits of using the SFC Prep 150 AP System?
The SFC Prep 150 AP System offers a number of benefits, including high-resolution separations, low solvent consumption, and fast cycle times. It also features a user-friendly interface and automated operation.

What types of samples can be separated using the SFC Prep 150 AP System?
The SFC Prep 150 AP System can be used to separate a wide range of samples, including pharmaceuticals, natural products, and food additives.

What type of detectors are compatible with the SFC Prep 150 AP System?
The SFC Prep 150 AP System is compatible with a variety of detectors, including UV, refractive index, evaporative light scattering, and mass spectrometry.

Does the SFC Prep 150 AP System come with a warranty?
Yes, the SFC Prep 150 AP System comes with a one-year warranty.