UHPLC/UPLC Systems

UHPLC/UPLC Systems

Waters Performance line of UHPLC/UPLC systems power up the sensitivity, repeatability, and robustness of your mass spectrometry (MS) analyses and improve the quality of your data.

Waters Performance line of UHPLC/UPLC systems power up the sensitivity, repeatability, and robustness of your mass spectrometry (MS) analyses and improve the quality of your data.
ACQUITY Premier System BSM FTN CH-A Xevo TQ-XS UniSpray Tray Bottles Angled

Instantly enhance the performance of virtually any liquid chromatography-mass spectrometry (LC-MS) experiment with any MS using Waters line of Performance UHPLC/UPLC Systems. With Performance UHPLC/UPLC Systems, you can support improvements in your separation resolution and reproducibility, pair with ACQUITY UPLC/UHPLC Columns for the sensitivity you need for demanding applications and gain enhanced selectivity regardless of molecule type or matrix complexity.

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Category: UHPLC/UPLC Systems
  • ACQUITY Premier System
    ACQUITY Premier System

    Minimize metal-sensitive analyte loss and improve recovery with the ACQUITY Premier System for ultra-performance liquid chromatography analysis.

  • ACQUITY Premier System with Multi-Dimensional Technology
    ACQUITY Premier System with Multi-Dimensional Technology

    Achieve maximum peak capacity and ensure accuracy and precision of the entire assay with the ACQUITY Premier System with Multi-Dimensional Technology.

  • ACQUITY UPLC H-Class PLUS System
    ACQUITY UPLC H-Class PLUS System

    Get the flexibility of quaternary or binary solvent blending with the advanced performance of UHPLC analysis with the ACQUITY UPLC H-Class PLUS System.

  • ACQUITY UPLC I-Class PLUS System
    ACQUITY UPLC I-Class PLUS System

    Improve your resolving power, lower your system volume and achieve the tallest, sharpest peaks with the ACQUITY UPLC I-Class PLUS System.

  • ACQUITY UPLC M-Class System
    ACQUITY UPLC M-Class System

    Achieve the sensitivity of micro- and nanoflow liquid chromatography with UPLC technology when you equip your lab with the ACQUITY UPLC M-Class System.

  • ACQUITY UPLC Systems with 2D LC Technology
    ACQUITY UPLC Systems with 2D LC Technology

    Ensure accuracy and precision for complex samples with the lowest dispersion two-dimensional chromatography system for maximum peak capacity, the ACQUITY UPLC Systems with 2D LC Technology.

  • PATROL UPLC Process Analysis System
    PATROL UPLC Process Analysis System

    Access real-time, chromatographic-quality analysis for in-process samples with the PATROL UPLC Process Analysis System..

UHPLC/UPLC Systems

The Waters Performance UHPLC/UPLC systems are designed to greatly enhance mass spectrometry (MS) analyses, providing increased sensitivity, remarkable repeatability, and enhanced robustness. Integration of these advanced systems improves data quality substantially. Engineered with precision, they optimize complex compound separation for precise analysis. Their superior chromatographic performance results in improved peak separation and resolution, enhancing the accuracy and reliability of MS measurements. The heightened sensitivity enables the detection of trace analyte amounts, valuable for challenging low-concentration applications. Exceptional repeatability ensures consistent, trustworthy results across multiple runs, crucial for complex or critical analyses. The systems' robustness enables stability in various conditions, reducing the risk of unexpected disruptions or result variations. In essence, the Waters Performance UHPLC/UPLC systems provide a comprehensive solution for enhancing MS analysis reliability and efficacy, offering high-quality data for insightful conclusions.

Enhance the results of virtually every liquid chromatography-mass spectrometry (LC-MS) experiment by harnessing the power of Waters' Performance UHPLC/UPLC Systems in conjunction with any MS variant. These advanced systems bring about heightened separation resolution and enhanced reproducibility, ensuring the precision and reliability of your analyses. The synergy achieved when pairing these systems with ACQUITY UPLC/UHPLC Columns provides the crucial sensitivity required for tackling demanding applications. The versatile design of the systems grants superior selectivity regardless of the nature of the molecules or the complexity of the sample matrix. This enhanced selectivity translates to improved overall performance and increased precision in analytical outcomes, paving the way for insightful conclusions and confident decision-making in your research endeavors.

UHPLC/UPLC Systems FAQs

1. What sets the Waters Performance line of UHPLC/UPLC systems apart from other chromatography systems?
The Waters Performance line of UHPLC/UPLC systems is designed to deliver exceptional resolution, sensitivity, and throughput for liquid chromatography applications. These systems utilize advanced technologies, such as ultra-high-pressure capabilities and low-dispersion fluidics, to achieve faster separations without compromising data quality.
They are optimized for modern workflows, offering seamless method transfer, precise solvent delivery, and compatibility with small-particle-size columns. Additionally, their rugged design and flexibility cater to a wide range of industries and applications, making them a standout choice for laboratories requiring robust and reliable performance.

2. What types of detectors are available for the Performance line?
The Waters Performance line of UHPLC/UPLC systems supports a variety of detectors to meet diverse analytical needs. Available options include Tunable UV/Vis (TUV), Photodiode Array (PDA), Fluorescence (FLR), Refractive Index (RI), Evaporative Light Scattering (ELSD), Conductivity (CD), Electrochemical (ECD), and the ACQUITY QDa Mass Detector (QDa). This wide selection ensures adaptability for different sample types and detection requirements, from routine quality control to advanced research applications.

3. How do these systems handle high backpressure requirements?
Waters Performance UHPLC/UPLC systems are engineered to operate at ultra-high pressures, often exceeding 15,000 psi, enabling the use of small-particle-size columns for improved resolution and faster separations. Advanced pump technology ensures consistent and precise solvent delivery even under high backpressure conditions. This capability allows the systems to maintain peak performance while handling challenging separations, such as those involving complex matrices or high-viscosity mobile phases, making them ideal for modern, high-throughput workflows.

4. What software platforms are compatible with the Waters Performance line?
The Waters Performance line is fully compatible with leading software platforms such as Empower Chromatography Data System (CDS), MassLynx, and UNIFI. These platforms offer comprehensive data management, analysis, and reporting tools, ensuring regulatory compliance and seamless integration with laboratory workflows. Empower CDS, in particular, is designed to meet stringent regulatory standards, providing secure data handling and robust audit trails.