Select the ideal Waters HPLC, UPLC, UHPLC, GPC, SFC, or SEC column for your application to simplify methods development, validation, and transfer across your organization.
Select the ideal Waters HPLC, UPLC, UHPLC, GPC, SFC, or SEC column for your application to simplify methods development, validation, and transfer across your organization.
Learn, Discover, and Shop Waters Bioseparations Products Using AI as Your Guide
Waters offers a wide array of column choices and formats, including HPLC, UPLC, UHPLC, GPC, SFC, and SEC, all built on reliable quality manufacturing that ensures that methods developed today will have the same repeatable results tomorrow.
Eliminate doubt in UPLC, UHPLC, and HPLC analysis applications with CORTECS Premier Columns, designed to increase sample throughput while providing reproducible data for all analytes.
Analyze gene therapeutics to learn about the potency and safety of your sample with Waters Gene Therapeutics (GTx) Size-Exclusion Chromatography (SEC) Columns, designed to provide accurate, high-throughput data.
Analytical size-exclusion chromatography columns are ideal for aggregate, monomer, and fragment analysis. Separate biomolecules by size in solution with Waters SEC Columns.
Discover how to achieve increases in LC efficiency, resolution, sensitivity, accuracy, speed, and reliability with ACQUITY sub-2-μm UPLC particle columns.
Experience XBridge HPLC and UHPLC Columns, ideal for methods development at extreme temperatures and mobile-phase pH. Explore XBridge BEH Column chemistries today.
Get superior selectivity and peak shape for basic compounds with XSelect HPLC and UHPLC Columns. Discover our CSH and high-strength silica columns. Visit today.
Separate complex synthetic polymers & macromolecules with ACQUITY Advanced Polymer Chromatography (APC) Columns for superior performance and reliability.
Achieve increases in sensitivity and analyte recovery while reducing column passivation time and mitigating unwanted analyte/surface interactions with ACQUITY Premier Columns.
Experience accurate and reproducible UPLC, UHPLC, and HPLC amino acid analysis with Pico•Tag, AccQ•Tag, and AccQ•Tag Ultra C18 Columns and Derivatization Kits.
Meet protein purification needs with Advanced Purification glass columns with silica, polymer or soft gel packings, designed for analytical & preparative LC instruments.
Increase bioanalysis recovery, reproducibility, and enhance LC and LC-MS sensitivity with Waters BioResolve Premier Columns, reversed-phase ion exchange columns designed for bioanalysis applications
Ideal for the isolation, analysis, and characterization of proteins and peptides, BioSuite Columns offer multiple chemistries: C18, cation and anion-exchange, SEC, & Phenyl.
Achieve fast, efficient, and reproducible online protein digestion with shorter sample preparation time with the Enzymate BEH Pepsin Column. Explore now.
Separate small and large molecules from interfering matrices in foods, pharmaceutical preparations, and natural products with Waters GPC Columns for organic and aqueous separations.
Develop high resolution, ion-pairing free analysis methods for synthetic oligonucleotides, digested nucleic acids, and capsid proteins with GTxResolve Premier BEH Amide Columns.
Reliable and robust critical quality attribute analysis of aggregates for Lipids nanoparticles (LNPs), nucleic acids, and viral vectors using GTxResolve columns.
Minimize non-specific adsorption (NSA) inherent to preparative chromatography while yielding high-purity results with MaxPeak Premier OBD Preparative Columns.
Enhance your workflow with MaxPeak Premier Protein SEC Columns, size-exclusion chromatography columns for the characterization of proteins and peptides.
Get higher resolution and efficiency for HPLC with Nova-Pak analytical and semi-preparative columns. Discover Nova-Pak C18, C8, Cyano & Phenyl column chemistries.
Achieve fast, efficient, lab-scale separations and greater throughput with Waters Preparative HPLC Columns, which provide predictable performance and easily scale from analytical to prep.
Achieve high-quality LC-based analyses & lab scale purifications of peptides and proteins with Protein-Pak IEX & HIC Columns, designed for use on HPLC and UPLC systems.
Get the alternative selectivity of normal-phase with the ease & reliability of reversed-phase chromatography with Waters analytical and prep SFC Columns for chiral and achiral separations.
Polymeric reversed-phase columns for basic compounds and applications requiring a broad pH range (2–12). Shodex RSpak Columns chemistries include DE-613 and DS-613.
Get exceptionally high mass loading for both analytical and preparative columns with SunFire HPLC Columns. Discover SunFire Silica, C8, and C18 columns.
Safeguard analytical HPLC, UHPLC, and UPLC columns from the effects of damaging particulates and chemical contaminates with VanGuard Cartridges and Pre-columns.
Discover unique separation selectivities with Waters Spherisorb Columns, the most widely referenced products for analytical and preparative column chromatography.
Experience XBridge Premier UHPLC Columns, designed to operate under extreme temperatures and mobile-phase pH while mitigating unwanted analyte/surface interactions.
Perform low and high pH drug discovery, method development and purification separations with XTerra hybrid particle technology HPLC columns. Learn more.
Separate acidic, basic, and neutral compounds with µBondaPak and BondaPak Columns. These HPLC columns are available in phenyl, C18, cyano and NH2 column chemistries.
Get reliable normal-phase chromatography separations with non-bonded, silica-based μPorasil and Porasil Columns. Research µPorasil/Porasil HPLC Column options.
Columns
Waters is renowned for its wide range of high-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography (UPLC) columns, offering advanced solutions for various analytical applications. These columns are designed to provide superior separation, retention, and peak resolution across a range of industries, from pharmaceuticals and environmental testing to food safety and biotechnology. Each Waters column is engineered with precision to ensure consistent performance, high reproducibility, and compatibility with different chromatography systems, making them essential components for any laboratory that relies on accurate and efficient separations.
Waters columns are available in various chemistries, particle sizes, and dimensions to meet the diverse needs of chromatography applications. Some of the most popular column families are:
ACQUITY UPLC Columns: ACQUITY UPLC columns are specifically designed for ultra-performance liquid chromatography systems, such as the ACQUITY UPLC and ACQUITY Arc systems. These columns utilize smaller particle sizes, typically less than 2 μm, which provide enhanced resolution, faster run times, and greater sensitivity. By minimizing band broadening and reducing analyte diffusion, these columns deliver sharper peaks and higher throughput, making them ideal for high-resolution separations and high-throughput labs. ACQUITY UPLC columns are widely used in pharmaceutical analysis, food testing, and environmental research, where precise and fast separations are critical.
Atlantis Columns: Atlantis columns are specifically engineered for the separation of polar compounds, which are typically difficult to retain and separate using traditional reversed-phase columns. With options for both reversed-phase and hydrophilic interaction chromatography (HILIC), Atlantis columns provide excellent polar compound retention and resolution. They are available in different chemistries, including T3, dC18, and unbonded HILIC, to accommodate a wide range of analytes and separation techniques. The superior retention capabilities of Atlantis columns make them ideal for pharmaceutical and bioanalytical research, where polar compound analysis is often required.
XSelect Columns: XSelect columns offer flexibility and performance across various applications, providing a broad range of column chemistries. These columns are designed for method development, allowing analysts to explore different retention characteristics, selectivity, and peak shape optimizations. With XSelect columns, you can choose between CSH (Charged Surface Hybrid) and HSS (High Strength Silica) particles, each offering distinct advantages depending on the separation needs. XSelect columns are commonly used in pharmaceutical research and other fields that require precise method development and optimization for complex separations.
SunFire Columns: SunFire columns are a popular choice for laboratories requiring excellent peak symmetry, high efficiency, and dependable performance across a wide pH range. These columns feature high-purity silica and advanced bonding technologies to deliver reliable results even under challenging conditions. SunFire columns are suitable for reversed-phase separations in pharmaceutical analysis, environmental testing, and food safety, where robust and reproducible results are essential.
CORTECS Columns: CORTECS columns utilize solid-core particle technology to offer high-efficiency separations with low backpressure. This makes them suitable for both high-performance and ultra-performance liquid chromatography applications. CORTECS columns provide a balance between performance and pressure, making them ideal for labs looking to enhance throughput without compromising resolution. They are available in C18, C8, and HILIC chemistries, offering flexibility for a range of applications.
All Waters columns offer numerous benefits that make them a preferred choice for laboratories across various industries. One of the primary advantages is their high efficiency, thanks to advanced materials and cutting-edge technologies that ensure superior separation performance. This results in sharper peaks, faster analysis times, and higher throughput, which is essential for labs looking to optimize productivity. Versatility is another key benefit, as Waters columns are designed to be compatible with a wide range of chromatography systems and applications, from traditional HPLC to the latest UPLC methods.
In addition to their performance, Waters columns are built for durability. They maintain consistent results even under harsh conditions, such as extreme pH levels or high temperatures, reducing the need for frequent replacements and lowering operational costs. Another critical advantage is reproducibility. Waters columns are engineered to deliver reliable and consistent results across multiple runs, ensuring data accuracy and repeatability—qualities that are essential for rigorous testing environments. Finally, with application-specific options available, Waters columns can be tailored to meet the unique requirements of different analyses, whether dealing with polar compounds, complex mixtures, or high-throughput demands. This range of benefits positions Waters' columns as an industry leader in chromatography solutions, including our columns.
FAQs
1.How do I choose the right Waters column for my application? Selecting the right Waters column depends on the specific needs of your application. It"s important to consider your sample types, desired separation performance, and system compatibility when choosing a column.
Discover Atlantis Premier Columns for high-performance liquid chromatography, designed to improve peak shape while mitigating unwanted interactions.
Eliminate doubt in UPLC, UHPLC, and HPLC analysis applications with CORTECS Premier Columns, designed to increase sample throughput while providing reproducible data for all analytes.
Discover XSelect Premier UHPLC Columns designed to improve peak shape and maximize selectivity while mitigating unwanted analyte/surface interactions.
Analyze gene therapeutics to learn about the potency and safety of your sample with Waters Gene Therapeutics (GTx) Size-Exclusion Chromatography (SEC) Columns, designed to provide accurate, high-throughput data.
Analytical size-exclusion chromatography columns are ideal for aggregate, monomer, and fragment analysis. Separate biomolecules by size in solution with Waters SEC Columns.
Discover how to achieve increases in LC efficiency, resolution, sensitivity, accuracy, speed, and reliability with ACQUITY sub-2-μm UPLC particle columns.
Maximize resolution and peak capacity for LC separations with CORTECS solid-core columns in 1.6 and 2.7 µm across 7 column chemistries.
Experience XBridge HPLC and UHPLC Columns, ideal for methods development at extreme temperatures and mobile-phase pH. Explore XBridge BEH Column chemistries today.
Improve chromatographic performance, retention, and stability for polar compounds with Atlantis HPLC Columns. Discover Atlantis C18 and HILIC column chemistries now.
Get superior selectivity and peak shape for basic compounds with XSelect HPLC and UHPLC Columns. Discover our CSH and high-strength silica columns. Visit today.
Separate complex synthetic polymers & macromolecules with ACQUITY Advanced Polymer Chromatography (APC) Columns for superior performance and reliability.
Achieve increases in sensitivity and analyte recovery while reducing column passivation time and mitigating unwanted analyte/surface interactions with ACQUITY Premier Columns.
Experience accurate and reproducible UPLC, UHPLC, and HPLC amino acid analysis with Pico•Tag, AccQ•Tag, and AccQ•Tag Ultra C18 Columns and Derivatization Kits.
Meet protein purification needs with Advanced Purification glass columns with silica, polymer or soft gel packings, designed for analytical & preparative LC instruments.
Streamline analytical challenges associated with mAb characterizations and associated biotherapeutic drug separations with BioResolve Columns.
Increase bioanalysis recovery, reproducibility, and enhance LC and LC-MS sensitivity with Waters BioResolve Premier Columns, reversed-phase ion exchange columns designed for bioanalysis applications
Ideal for the isolation, analysis, and characterization of proteins and peptides, BioSuite Columns offer multiple chemistries: C18, cation and anion-exchange, SEC, & Phenyl.
Separate and isolate peptides, proteins, and natural products with Delta-Pak HPLC Columns for large molecule separations.
Achieve fast, efficient, and reproducible online protein digestion with shorter sample preparation time with the Enzymate BEH Pepsin Column. Explore now.
Separate small and large molecules from interfering matrices in foods, pharmaceutical preparations, and natural products with Waters GPC Columns for organic and aqueous separations.
Develop high resolution, ion-pairing free analysis methods for synthetic oligonucleotides, digested nucleic acids, and capsid proteins with GTxResolve Premier BEH Amide Columns.
Reliable and robust critical quality attribute analysis of aggregates for Lipids nanoparticles (LNPs), nucleic acids, and viral vectors using GTxResolve columns.
Perform complicated synthesis, analysis and other HPLC assays with Gen-Pak FAX Anion-Exchange Columns. Explore our Gen-Pak oligonucleotide synthesis columns now.
For a quick, easy and reproducible protocol for desalting acidic, basic and large globular proteins, choose MassPREP On-line Desalting Cartridges.
Minimize non-specific adsorption (NSA) inherent to preparative chromatography while yielding high-purity results with MaxPeak Premier OBD Preparative Columns.
Enhance your workflow with MaxPeak Premier Protein SEC Columns, size-exclusion chromatography columns for the characterization of proteins and peptides.
Meet high efficiency and selectivity requirements for complex peptide and protein separations with Waters nano and microflow LC-MS Columns.
Get higher resolution and efficiency for HPLC with Nova-Pak analytical and semi-preparative columns. Discover Nova-Pak C18, C8, Cyano & Phenyl column chemistries.
Achieve fast, efficient, lab-scale separations and greater throughput with Waters Preparative HPLC Columns, which provide predictable performance and easily scale from analytical to prep.
Achieve high-quality LC-based analyses & lab scale purifications of peptides and proteins with Protein-Pak IEX & HIC Columns, designed for use on HPLC and UPLC systems.
Achieve high retention and high resolution of polar compounds with non-endcapped Resolve Columns available in C18, C8 and Cyano column chemistries.
Get the alternative selectivity of normal-phase with the ease & reliability of reversed-phase chromatography with Waters analytical and prep SFC Columns for chiral and achiral separations.
Polymeric reversed-phase columns for basic compounds and applications requiring a broad pH range (2–12). Shodex RSpak Columns chemistries include DE-613 and DS-613.
Get exceptionally high mass loading for both analytical and preparative columns with SunFire HPLC Columns. Discover SunFire Silica, C8, and C18 columns.
Get predictable analytical performance and ensure batch-to-batch reproducibility with high purity silica-based Symmetry HPLC Columns.
Safeguard analytical HPLC, UHPLC, and UPLC columns from the effects of damaging particulates and chemical contaminates with VanGuard Cartridges and Pre-columns.
Analyze insulin products for impurities with Waters Insulin HMWP Gel Filtration HPLC Columns. Learn about insulin gel filtration column packing now.
Get superior peak identification and quantitation for Polyaromatic Hydrocarbons (PAHs) compounds with Waters PAH C18 HPLC Columns.
Discover unique separation selectivities with Waters Spherisorb Columns, the most widely referenced products for analytical and preparative column chromatography.
Experience XBridge Premier UHPLC Columns, designed to operate under extreme temperatures and mobile-phase pH while mitigating unwanted analyte/surface interactions.
Perform low and high pH drug discovery, method development and purification separations with XTerra hybrid particle technology HPLC columns. Learn more.
Separate acidic, basic, and neutral compounds with µBondaPak and BondaPak Columns. These HPLC columns are available in phenyl, C18, cyano and NH2 column chemistries.
Get reliable normal-phase chromatography separations with non-bonded, silica-based μPorasil and Porasil Columns. Research µPorasil/Porasil HPLC Column options.