Biopharma and Pharma

Biopharma and Pharma

Waters analytical workflow solutions translate complexity into clarity, enabling your lab to optimize operations and develop large and small molecule therapeutics with our powerful portfolio of products, services, and support.

Waters analytical workflow solutions translate complexity into clarity, enabling your lab to optimize operations and develop large and small molecule therapeutics with our powerful portfolio of products, services, and support.
Learn how to achieve high performance oligonucleotide preparative chromatography by utilizing XBridge Oligonucleotide OBD Prep Columns and efficient method optimization considerations

Organizations throughout the pharmaceutical and life sciences industry are increasing their investments in pharmaceutical and biopharmaceutical development as global demand increases for new and life-saving therapies. In these rapidly-evolving fields, there is a widespread need for application-appropriate, high-value technologies for large and small molecule analysis.

Strategic characterization technologies provide unique insights into the development potential of large molecule therapeutics. A first-line analysis of complex biotherapeutics that is rich with information can save significant time and development costs during production. Waters latest innovations in LC, LC-MS, and informatics are designed to address the multi-faceted analytical needs of large molecule characterization – from innovator biopharmaceuticals, to biosimilars, to antibody drug conjugates – and to keep pace with the regulatory changes that impact development laboratories.

For small molecule analysis, Waters helps pharmaceutical organizations address escalating challenges with sample preparation, separations science, standards and reagents, laboratory information management, liquid chromatography, mass spectrometry, and industry-leading support designed to solve critical analytical problems and increase efficiencies. We help your lab achieve profound discoveries, optimize operations, and ensure regulatory compliance – turning global industry challenges into medicines that offer hope.


We offer tools for biomolecular separations, mass analysis and biophysical characterization to support the commercialization of cell and gene therapy products.

Meet your advanced protein and peptide characterization, routine LC analysis and bioprocessing monitoring requirements with Waters analytical technologies for protein and peptide therapies.

Analyses performed to advance traditional small molecule drugs: Medicinal chemistry, bioanalysis or small and large molecules, drug metabolism, and pharmacokinetics (DMPK), methods development, impurities analysis, natural products, quality control (QC), process analysis, and manufacturing.

Accelerate biotherapeutics discovery and development timelines with Waters Process Analytical Technology (PAT) solutions for upstream and downstream bioprocessing.

A portfolio of solutions to support the pharmaceutical research and development, focusing on drug metabolism and pharmacokinetics (DMPK).

Minimize method variability and generate more consistent reportable results with advanced chromatography, mass detection, and software solutions from Waters.

Identification and quantification of extractables, leachables, and non-intentionally added substances using Waters purpose-built systems, software, and consumables.
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FAQs about Biopharma and Pharma

What technologies does Waters offer for protein analysis?

Waters offers a comprehensive suite of technologies for protein analysis, including Ultra-Performance Liquid Chromatography (UPLC), High-Performance Liquid Chromatography (HPLC), and Mass Spectrometry (MS).

Waters' ACQUITY UPLC systems, combined with advanced columns like the ACQUITY UPLC BEH C18, provide a high-resolution separation of complex protein mixtures. Additionally, Waters' mass spectrometry solutions, such as the Xevo TQ-S micro and SYNAPT G2-Si, offer precise identification and quantification of proteins and peptides.

What is the role of mass spectrometry in biopharma applications?

Mass spectrometry (MS) is a crucial tool in biopharma applications due to its high sensitivity, specificity, and ability to analyze a wide range of biomolecules. It plays a vital role in the identification and quantification of proteins, peptides, and metabolites, providing detailed molecular information that is essential for drug discovery and development. Waters' MS systems, such as the Xevo TQ-S and SYNAPT G2-Si, are designed to meet the rigorous demands of biopharma research, offering robust and reliable performance.

Can Waters' products help detect and quantify impurities in pharmaceuticals?

Waters' products are specifically designed to detect and quantify impurities in pharmaceuticals. Waters' UPLC and HPLC systems, combined with advanced detection methods like photodiode array (PDA) detectors and mass spectrometry, provide high-resolution separation and accurate identification of impurities.

What are the advantages of using Waters' solutions for monoclonal antibody characterization?

Waters' solutions offer several advantages for monoclonal antibody (mAb) characterization, including high resolution, sensitivity, and robustness. Waters' UPLC and HPLC systems, such as the ACQUITY UPLC H-Class, provide precise separation of mAbs and their variants, enabling detailed analysis of glycosylation patterns, charge variants, and aggregation. Mass spectrometry solutions like the Xevo G2-XS QTof provide high-resolution mass analysis, facilitating the identification and quantification of mAb components.