2424 Evaporative Light Scattering (ELS) Detector

2424 Evaporative Light Scattering (ELS) Detector

Putting confidence in your detection strategy

Putting confidence in your detection strategy

Detecting semi- and non-volatile compounds with minimal UV absorbance is a challenge. The Waters 2424 Evaporative Light Scattering (ELS) Detector, with its compact and innovative design, offers near universal detection of non-volatile and semi-volatile sample components. 

The 2424 ELS Detector is compatible with both isocratic and gradient separations and has nebulizer options to cover a wide range of analytical and microbore flow rates. By adding the orthogonality of ELS to your detection strategy, you increase peak detection confidence across a wide application space. The 2424 ELS Detector can be used as part of an LC or LC-MS system under the control of Empower or MassLynx software or can be operated as a standalone detector.

2424 ELS Detector 2424 Evaporative Light Scattering (ELS) Detector

Specifications

Nebulizers

High-flow rate (standard with detector)

300 to 3000 μL/min, (gas flow at 1.80 L/min at 25 psi)

Optional low-flow rate

50 to 500 μL/min, (gas flow at 0.77 L/min at 25 psi)

Temperature control

Nebulizer heater power

0% to 100%

Nebulizer cooler

On/off

Drift tube

Ambient +5.0 to 100.0 °C; 0.1 °C increments

Optional external column heater

Ambient +5.0 to 150.0 °C; 1.0 °C increments

Gas supply

Nitrogen, to be supplied at least 65 psi

Gain setting

0 to 1000

Filter time constant

Hamming, 0.0 to 5.0 s

Sampling rate

Up to 80 points/s

Measurement range

0.1 to 2000.0 LSU

Optics

Heated optics bench (constant 50 °C)

Light source

Tungsten halogen polychromatic front mounted, pre-aligned, user installable

Warranty: 2000 hours or 1 year warranty (whichever comes first)

Detector

Photomultiplier tube

Scattering angle

60 degrees

Wetted materials

316 stainless-steel, aluminum, viton, PTFE, FEP, silicone rubber, polyethylene, polyurethane

Overview

  • Active nebulizer heating and cooling for method optimization and rapid stabilization
  • 60° scatter angle detection to minimize stray light and optics polarization for long-term optimal sensitivity
  • Optimal energy output for improved bench-to-bench repeatability

Recommended Use: For detection of non-volatile and semi-volatile sample components.

Features Header

Features Header

Quantification for your entire sample

Finding the right balance in a detector designed for evaporative light scattering detection can be the difference between good sensitivity of semi-volatile components and high peak dispersion. The 2424 ELS Detector was designed with this critical balance in mind and delivers reproducible quantification for semi-volatile components without adding high dispersion to fast LC separations. Sample components that elute in the column void volume can be difficult to detect with many techniques, creating an issue of particular concern for strong UV absorbing diluents such as dimethyl sulfoxide (DMSO). The desolvation characteristics of the 2424 ELS Detector can remove the sample diluent interference to give visibility to unretained components in your sample.

Complex applications with gradient analysis

Whether trying to monitor a complex process such as the consistent production of food oils or verifying their authenticity to prevent adulteration, the use of gradient analysis is important for providing a wider separation range of your samples. The 2424 ELS Detector is entirely compatible with gradient analysis, and with significantly reduced stabilization times as compared to other ELS detectors, you can get consistent answers, faster.

Enhance your existing detection capabilities

For applications where not all components have a UV chromophore, adding ELS detection expands the visibility of your sample by providing a complementary detection capability. The 2424 ELS Detector offers reference energy monitoring for consistent long-term signal, 60 degrees scatter angle detection to minimize stray light and optics polarization and long-term optimal sensitivity, and normalized energy output for improved bench-to-bench repeatability.

Boost confidence in results with a complete chromatographic picture

Pair a 2424 ELS Detector with a Waters 2489 UV/Vis Detector and SQ Detector 2 single quadrupole mass detector, and achieve the capability to:

  • Derive more complete peak information in one chromatographic run.
  • Detect molecules that lack a UV/Vis chromophore, complementing absorbance detector information.
  • Analyze compounds that don’t ionize well by mass spectrometry (MS).

Select the right chromatographic data system for your laboratory’s needs from Empower or MassLynx software. The 2424 ELS Detector is also compliance-ready as part of a Waters LC system – all supported within the Systems Qualification Tool (SystemsQT) technology.

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2424 Evaporative Light Scattering (ELS) Detector

The Waters 2424 Evaporative Light Scattering (ELS) Detector represents a significant advance in the detection of semi-volatile and non-volatile compounds that exhibit minimal UV absorbance, presenting a robust solution for complex analytical challenges. This detector's innovative design and compatibility with both isocratic and gradient separations make it an invaluable tool for increasing confidence in peak detection across a broad spectrum of applications.

Equipped to handle analytical and microbore flow rates with variable nebulizer options, the 2424 ELS Detector integrates seamlessly into LC or LC-MS systems. It can be operated under the control of Empower or MassLynx software, or as a standalone unit, enhancing flexibility in laboratory workflows. Its active nebulizer temperature control enables rapid method optimization and stabilization, ensuring consistent performance.

A key feature of this detector is its 60° scatter angle detection, which effectively minimizes stray light and optics polarization, enhancing long-term sensitivity and reliability. Such capabilities ensure optimal energy output, improving bench-to-bench repeatability and making the 2424 ELS Detector a must-have for laboratories requiring precise quantification of non-volatile and semi-volatile components.

The challenge of detecting compounds that elute in the column void volume, such as those in strong UV-absorbing diluents like DMSO, is adeptly met by the desolvation characteristics of the 2424 ELS Detector. This feature allows for the clear visibility of unretained components, removing sample diluent interference and enhancing analytical accuracy.

For more complex applications, like monitoring the production of food oils or verifying authenticity to prevent adulteration, the compatibility with gradient analysis is crucial. The 2424 ELS Detector excels here as well, providing consistent results quickly due to its reduced stabilization times compared to other ELS detectors. This capability is essential for labs that need to conduct comprehensive and swift analyses.

Additionally, when combined with Waters 2489 UV/Vis Detector and SQ Detector 2 single quadrupole mass detector, the 2424 ELS Detector allows for a more complete chromatographic picture. This combination facilitates the detection of molecules lacking a UV/Vis chromophore and complements information from absorbance detectors, covering gaps left by mass spectrometry in analyzing non-ionizing compounds.

The 2424 ELS Detector is not only powerful and versatile but also compliance-ready as part of a Waters LC system. It supports integration with Systems Qualification Tool (SystemsQT) technology, ensuring that it meets the rigorous standards required in regulated environments.

This detector is a comprehensive solution for laboratories aiming to enhance their detection capabilities without compromising on efficiency or accuracy, making it an essential addition to any chromatographic setup.